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Impact of thrombus burden on long-term clinical outcomes in patients with either anterior or non-anterior ST-segment elevation myocardial infarction
- Source :
- Journal of Thrombosis and Thrombolysis, 54(1), 47-57. Springer Netherlands
- Publication Year :
- 2022
-
Abstract
- Large thrombus burden (LTB) during ST-segment elevation myocardial infarction (STEMI) could translate into worse clinical outcomes. The impact of a LTB in terms of long-term clinical outcomes on different myocardial infarct territories has not yet been fully evaluated. From April 2002 to December 2004, consecutive patients with STEMI undergoing percutaneous coronary intervention with drug eluting stent were evaluated. The study sample was stratified in two groups: anterior STEMI and non-anterior STEMI. LTB was considered as a thrombus larger than or equal to 2-vessel diameters, and small thrombus burden less than 2-vessel diameters. Major adverse cardiac events (MACE) were evaluated at 10-year and survival data were collected up to 15-year. A total of 812 patients were evaluated, 6 patients were excluded due to inadequate angiographic images, 410 (50.9%) had an anterior STEMI and 396 (49.1%) a non-anterior STEMI. Patients with LTB had higher rates of 10-year mortality (aHR 2.27, 95%CI 1.42–3.63; p = 0.001) and 10-year MACE (aHR 1.46, 95%CI 1.03–2.08; p = 0.033) in anterior STEMI, but not in non-anterior STEMI (aHR 0.78, 95%CI 0.49–1.24; p = 0.298; aHR 0.71, 95%CI 0.50–1.02; p = 0.062). LTB was associated with increased 30-day mortality (aHR 5.60, 95%CI 2.49–12.61; p
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Myocardial Infarction
Coronary Angiography
Anterior ST segment elevation
Percutaneous Coronary Intervention
Internal medicine
medicine
Humans
Myocardial infarction
cardiovascular diseases
Thrombus
Non-ST Elevated Myocardial Infarction
Hematology
business.industry
Coronary Thrombosis
Percutaneous coronary intervention
Drug-Eluting Stents
medicine.disease
Treatment Outcome
Thrombus burden
Drug-eluting stent
Cardiology
ST Elevation Myocardial Infarction
Cardiology and Cardiovascular Medicine
business
Mace
Subjects
Details
- Language :
- English
- ISSN :
- 09295305
- Database :
- OpenAIRE
- Journal :
- Journal of Thrombosis and Thrombolysis, 54(1), 47-57. Springer Netherlands
- Accession number :
- edsair.doi.dedup.....57037d634333fcc72e9973c3c635ad0c