Whole-genome sequencing analysis of the cardiometabolic proteome

Authors :: Grace Png
Emmanouil Tsafantakis
Iris Fischer
N. William Rayner
Daniel Suveges
George Dedoussis
Andrei Barysenka
Arthur Gilly
Sonja Neumeyer
Lorraine Southam
Thea Bjørnland
Maria Karaleftheri
Young-Chan Park
Eleftheria Zeggini
Fischer, Iris [0000-0002-5080-1223]
Zeggini, Eleftheria [0000-0003-4238-659X]
Apollo - University of Cambridge Repository
Source :: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020), Nature Communications, Nat. Commun. 11:6336 (2020)
Publication Year :: 2020
Publisher :: Nature Portfolio, 2020.
Abstract: The human proteome is a crucial intermediate between complex diseases and their genetic and environmental components, and an important source of drug development targets and biomarkers. Here, we comprehensively assess the genetic architecture of 257 circulating protein biomarkers of cardiometabolic relevance through high-depth (22.5×) whole-genome sequencing (WGS) in 1328 individuals. We discover 131 independent sequence variant associations (P<br />The human proteome represents a crucial link between complex disease and genetic/environmental factors. Here, the authors investigate 257 cardiometabolic-relevant protein biomarkers in whole genome sequencing data from 1328 individuals, revealing the genetic architecture underlying biomarker variation.

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