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Comparing self-reported medication adherence measures with hair antiretroviral concentration among people living with HIV in Guangxi, China
- Source :
- AIDS Research and Therapy, AIDS Research and Therapy, Vol 17, Iss 1, Pp 1-8 (2020)
- Publication Year :
- 2019
-
Abstract
- Background Antiretroviral adherence is essential to HIV treatment efficacy. Various self-reported measures are commonly used for assessing antiretroviral adherence. Limited data are available regarding the validity of those self-reported measures in comparison with long-term objective biomarkers of adherence measures such as hair measures. Methods Self-reported adherence (frequency, percentage, and visual analog scale [VAS]) and hair tenofovir concentration were evaluated at a single time point from 268 people living with HIV in China. The responses to each of three self-reported measures were converted into percentage and then dichotomized as “optimal” (100%) vs. “suboptimal” (less than 100%) adherence. Two composite adherence scores (CAS) were created from the three self-reported measures: (1) an overall adherence was the average percentage of the three self-reported measures; (2) responses were termed optimal adherence if participants reporting optimal adherence in all three self-reported measures, while were termed suboptimal adherence. Hair tenofovir concentration was also dichotomized as “optimal” (above the limit of quantitation, 36 pg/mg) vs. “suboptimal” adherence (blow 36 pg/mg). Spearman correlation, kappa statistics, and logistic regression analysis were used to calculate the correlations, agreements, and predictions of self-reported measures with hair measure, respectively. Results Overall adherence, but any of the three self-reported adherence, was correlated with hair tenofovir concentration (r = 0.13, p p Conclusion VAS may be a good individual self-reported measure for antiretroviral adherence, and CAS may be a good composite self-reported measure for antiretroviral adherence.
- Subjects :
- lcsh:Immunologic diseases. Allergy
0301 basic medicine
Adult
Male
medicine.medical_specialty
China
Tenofovir
Visual analogue scale
Anti-HIV Agents
Human immunodeficiency virus (HIV)
Medication adherence
HIV Infections
Antiretroviral adherence
medicine.disease_cause
Logistic regression
Medication Adherence
03 medical and health sciences
0302 clinical medicine
Cohen's kappa
Virology
Internal medicine
Surveys and Questionnaires
medicine
Humans
Pharmacology (medical)
030212 general & internal medicine
Hiv treatment
Self report
business.industry
Research
Middle Aged
030112 virology
3. Good health
People living with HIV
Hair concentration
Treatment Outcome
Molecular Medicine
Female
Self Report
lcsh:RC581-607
business
Self-report
medicine.drug
Hair
Subjects
Details
- ISSN :
- 17426405
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- AIDS research and therapy
- Accession number :
- edsair.doi.dedup.....571be92aa77cfcca31801cc152d7bae8