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Neuropathology in Drosophila mutants with increased seizure susceptibility
- Source :
- Genetics. 178(2)
- Publication Year :
- 2008
-
Abstract
- Genetic factors are known to contribute to seizure susceptibility, although the long-term effects of these predisposing factors on neuronal viability remain unclear. To examine the consequences of genetic factors conferring increased seizure susceptibility, we surveyed a class of Drosophila mutants that exhibit seizures and paralysis following mechanical stimulation. These bang-sensitive seizure mutants exhibit shortened life spans and age-dependent neurodegeneration. Because the increased seizure susceptibility in these mutants likely results from altered metabolism and since the Na+/K+ ATPase consumes the majority of ATP in neurons, we examined the effect of ATPĪ± mutations in combination with bang-sensitive mutations. We found that double mutants exhibit strikingly reduced life spans and age-dependent uncoordination and inactivity. These results emphasize the importance of proper cellular metabolism in maintaining both the activity and viability of neurons.
- Subjects :
- Nervous system
ATPase
media_common.quotation_subject
Mutant
Longevity
Stimulation
Neuropathology
Investigations
medicine.disease_cause
Nervous System
Seizures
Genetics
medicine
Animals
Genetic Predisposition to Disease
media_common
Mutation
biology
Neurodegeneration
medicine.disease
medicine.anatomical_structure
biology.protein
Drosophila
Subjects
Details
- ISSN :
- 00166731
- Volume :
- 178
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Genetics
- Accession number :
- edsair.doi.dedup.....572b9a2556a4b0facd7dfd217c577f17