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How does extracerebral trauma affect the clinical value of S100B measurements?
- Source :
- Emergency Medicine Journal : EMJ
- Publication Year :
- 2010
- Publisher :
- BMJ Group, 2010.
-
Abstract
- Background Protein S100B has proven to be a useful biomarker for cerebral damage. The predictive ability of S100B may, however, be affected by extracerebral injuries. The aim of this study was to investigate serum levels of S100B in patients with either isolated head injury (IHI), multi trauma with head injury (MTHI), or no head injury (NHI). The primary aim was to assess if a significant difference in serum levels of S100B could be found between IHI and MTHI patients. Methods Patients (233) were primarily admitted to the trauma centre. Serum samples were drawn on admission and 6 h after trauma and then stored at −80°C until analysed. Variables included Abbreviated Injury Scale (AIS) for head trauma, Injury Severity Score (ISS) and 30-day survival. Results Two patients could not be classified. IHI occurred in 28, MTHI in 102 and NHI was found in 101. The median S100B concentrations on arrival were 0.47, 1.68 and 0.49 μg/l, respectively (p
- Subjects :
- Adult
Male
medicine.medical_specialty
assessment
Denmark
S100 Calcium Binding Protein beta Subunit
Critical Care and Intensive Care Medicine
Affect (psychology)
S100B
Head trauma
Injury Severity Score
traumatic brain damage
multi trauma
Predictive Value of Tests
medicine
Humans
Nerve Growth Factors
cost-effectiveness
research
Abbreviated Injury Scale
business.industry
Multiple Trauma
neurology
Head injury
S100 Proteins
General Medicine
Middle Aged
medicine.disease
Surgery
trauma
Predictive value of tests
Anesthesia
Brain Injuries
Emergency Medicine
Clinical value
Biomarker (medicine)
Original Article
Female
business
mental health
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 14720213 and 14720205
- Volume :
- 28
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Emergency Medicine Journal : EMJ
- Accession number :
- edsair.doi.dedup.....572dfbe13e98e060c96487b47a522564