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Risk Factors for Ebola Exposure in Health Care Workers in Boende, Tshuapa Province, Democratic Republic of the Congo
- Source :
- The Journal of infectious diseases, vol 226, iss 4
- Publication Year :
- 2022
- Publisher :
- eScholarship, University of California, 2022.
-
Abstract
- Background Health care workers (HCW) are more likely to be exposed to Ebola virus (EBOV) during an outbreak compared to people in the general population due to close physical contact with patients and potential exposure to infectious fluids. However, not all will fall ill. Despite evidence of subclinical and paucisymptomatic Ebola virus disease (EVD), prevalence and associated risk factors remain unknown. Methods We conducted a serosurvey among HCW in Boende, Tshuapa Province, Democratic Republic of Congo. Human anti-EBOV glycoprotein IgG titers were measured using a commercially available ELISA kit. We assessed associations between anti-EBOV IgG seroreactivity, defined as ≥2.5 units/mL, and risk factors using univariable and multivariable logistic regression. Sensitivity analyses explored a more conservative cutoff, >5 units/mL. Results Overall, 22.5% of HCWs were seroreactive for EBOV. In multivariable analyses, using any form of personal protective equipment when interacting with a confirmed, probable, or suspect EVD case was negatively associated with seroreactivity (adjusted odds ratio, 0.23; 95% confidence interval, .07–.73). Discussion Our results suggest high exposure to EBOV among HCWs and provide additional evidence for asymptomatic or minimally symptomatic EVD. Further studies should be conducted to determine the probability of onward transmission and if seroreactivity is associated with immunity.
- Subjects :
- Health Personnel
030231 tropical medicine
Population
Disease
medicine.disease_cause
Logistic regression
Asymptomatic
Medical and Health Sciences
Microbiology
health care workers
Disease Outbreaks
Vaccine Related
03 medical and health sciences
0302 clinical medicine
Risk Factors
Clinical Research
Environmental health
Biodefense
medicine
Immunology and Allergy
Humans
030212 general & internal medicine
education
Subclinical infection
education.field_of_study
Ebola virus
business.industry
Transmission (medicine)
Prevention
Outbreak
Hemorrhagic Fever, Ebola
Biological Sciences
Ebolavirus
Emerging Infectious Diseases
Infectious Diseases
Good Health and Well Being
Immunoglobulin G
Ebola
Democratic Republic of the Congo
Hemorrhagic Fever
medicine.symptom
business
Infection
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases, vol 226, iss 4
- Accession number :
- edsair.doi.dedup.....573e4db56fe4cf5dd2ff83bab11d966a