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Hirsutella sinensis Inhibits Lewis Lung Cancer via Tumor Microenvironment Effector T Cells in Mice
- Source :
- The American journal of Chinese medicine. 46(4)
- Publication Year :
- 2018
-
Abstract
- Hirsutella sinensis fungus (HSF) is an artificial substitute of the well-known medicine Cordyceps sinensis with similar beneficial effects in humans. We previously found that HSF can regulate immune function and inhibit tumor growth; however, the mechanisms involved in these effects were still unclear. Accordingly, in this study, we investigated the effects of HSF on immune cell subsets in the tumor microenvironment in mice. The results showed that HSF inhibited Lewis lung cancer growth, alleviated abnormalities in routine blood tests, and enhanced tumor-infiltrating T cells, particularly the proportion of effector CD8[Formula: see text] T cells. In addition, HSF also ameliorated the immune-suppressive microenvironment and decreased the proportions of regulatory T cell and myeloid-derived suppressor cell populations. To confirm the effects of HSF on promotion of effector CD8[Formula: see text] T-cell production, we further evaluated changes in postoperative metastasis following treatment with HSF. Indeed, orthotopic lung metastasis was significantly suppressed, and survival times were increased in HSF-treated mice. Taken together, our findings suggested that HSF inhibited Lewis lung cancer by enhancing the population of effective CD8[Formula: see text] T cells.
- Subjects :
- 0301 basic medicine
Male
endocrine system
Lung Neoplasms
Regulatory T cell
medicine.medical_treatment
Population
Antineoplastic Agents
Biology
CD8-Positive T-Lymphocytes
T-Lymphocytes, Regulatory
03 medical and health sciences
Carcinoma, Lewis Lung
0302 clinical medicine
Immune system
Ascomycota
medicine
Immune Tolerance
Tumor Cells, Cultured
Tumor Microenvironment
Animals
Lung cancer
education
education.field_of_study
Tumor microenvironment
Effector
Myeloid-Derived Suppressor Cells
General Medicine
Immunotherapy
medicine.disease
Lymphocyte Subsets
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Complementary and alternative medicine
030220 oncology & carcinogenesis
Cordyceps
Cancer research
CD8
Subjects
Details
- ISSN :
- 17936853
- Volume :
- 46
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The American journal of Chinese medicine
- Accession number :
- edsair.doi.dedup.....578d74fc1fd585a743e54a6d0bbfd78a