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Pargyline and gamma-butyrolactone enhance tyrosine hydroxylase immunostaining of nigrostriatal axons

Pargyline and gamma-butyrolactone enhance tyrosine hydroxylase immunostaining of nigrostriatal axons

Authors :
John F. Reinhard
Najwa Haykal-Coates
James P. O'Callaghan
Karl F. Jensen
Source :
Brain research. 556(2)
Publication Year :
1991

Abstract

Administration of pargyline or gamma-butyrolactone enhanced immunostaining of tyrosine hydroxylase immunoreactive axons in the striatum. The qualitative characteristics of the enhancement were compound dependent and the enhancement was not associated with an increase in the amount of tyrosine hydroxylase within the striatum. These results demonstrate the pharmacological enhancement of immunostaining for neurotransmitter synthetic enzymes in the absence of increased synthesis.

Details

ISSN :
00068993
Volume :
556
Issue :
2
Database :
OpenAIRE
Journal :
Brain research
Accession number :
edsair.doi.dedup.....57a97298dfa80d0352100384514c27c4