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Dose-Dependent Effect of Polystyrene Microplastics on the Testicular Tissues of the Male Sprague Dawley Rats
- Source :
- Dose-Response, Dose-Response, Vol 19 (2021)
- Publication Year :
- 2021
- Publisher :
- SAGE Publications, 2021.
-
Abstract
- Due to the continuous increase in polystyrene microplastics (PS MPs) incorporation in the environment, growing number of adverse effects on living organisms and ecosystem have become a global concern. Therefore, current study was planned to elucidate the impacts of 5 different concentrations control, 2, 20, 200, and 2000 μgL-1 of PS MPs on testicular tissues of rats. PS MPs significantly reduced the activities of antioxidant enzymes (catalase, superoxide dismutase and peroxidase) as well as total protein contents, while elevated the level of lipid peroxidation and reactive oxygen species. Moreover, expressions of steroidogenic enzymes (3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and steroidogenic acute regulatory protein) as well as the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) in plasma, intra-testicular testosterone and plasma testosterone were reduced and a significant ( P < 0.05) reduction was noticed in the sperm count, motility and viability. Furthermore, PS MPs significantly up-regulated the expressions of Bax and caspase-3, while down-regulated the Bcl-2 expression. The histomorphological assessment revealed significant damages in the testicles as well as decrease in the number of germ cells (spermatogenic, spermatocytes and spermatids). Collectively, PS MPs generated oxidative stress (OS) and caused potential damage to the testicles of rats in a dose-dependent manner.
- Subjects :
- 0301 basic medicine
endocrine system
medicine.medical_specialty
male reproductive system
Health, Toxicology and Mutagenesis
RM1-950
010501 environmental sciences
Toxicology
medicine.disease_cause
01 natural sciences
Superoxide dismutase
Lipid peroxidation
03 medical and health sciences
chemistry.chemical_compound
testicular damage
Internal medicine
medicine
oxidative stress
Testosterone
0105 earth and related environmental sciences
chemistry.chemical_classification
Reactive oxygen species
Chemical Health and Safety
biology
Steroidogenic acute regulatory protein
Public Health, Environmental and Occupational Health
polystyrene microplastics (PS MPS)
spermatogenesis
030104 developmental biology
Endocrinology
chemistry
biology.protein
Original Article
Therapeutics. Pharmacology
Luteinizing hormone
Spermatogenesis
Oxidative stress
Subjects
Details
- ISSN :
- 15593258
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Dose-Response
- Accession number :
- edsair.doi.dedup.....57b7e26bf4a48a2d795a0d0575e2bb12
- Full Text :
- https://doi.org/10.1177/15593258211019882