Back to Search
Start Over
Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice
- Source :
- Synapse. 64:503-510
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Peripheral and central leptin administration has been shown to mediate central dopamine (DA) signaling. Leptin-receptor deficient rodents show decreased DA D2 receptor (D2R) binding in striatum and unique DA profiles compared to controls. Leptin-deficient mice show increased DA activity in reward-related brain regions. The objective of this study was to examine whether basal D2R binding differences contribute to the phenotypic behaviors of leptin deficient ob/ob mice and whether D2R binding is altered in response to peripheral leptin treatment in these mice. Leptin decreased body weight, food intake, and plasma insulin concentration in ob/ob mice but not in wild-type mice. Striatal basal D2R binding (measured with autoradiography [3H] spiperone) did not differ between ob/ob and wild-type mice but the response to leptin did. In wild-type mice leptin decreased striatal D2R binding whereas in ob/ob mice leptin increased D2R binding. Our findings provide further evidence that leptin modulates D2 receptor expression in striatum and that these effects are genotype/phenotype dependent.
- Subjects :
- Leptin
Male
Spiperone
medicine.medical_specialty
Genotype
Caudate nucleus
Mice, Obese
Striatum
Biology
Tritium
Nucleus Accumbens
Article
Eating
Mice
Cellular and Molecular Neuroscience
Dopamine
Dopamine receptor D2
Internal medicine
Weight Loss
medicine
Animals
Insulin
Receptor
Analysis of Variance
Leptin Deficiency
Receptors, Dopamine D2
digestive, oral, and skin physiology
Putamen
Corpus Striatum
Mice, Inbred C57BL
Phenotype
Endocrinology
Autoradiography
Caudate Nucleus
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 10982396 and 08874476
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Synapse
- Accession number :
- edsair.doi.dedup.....57d278ce5f888ebb7fe9cbff3e2c0e3d