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Molecular mechanisms of regulation of HTLV-1 gene expression and its association with leukemogenesis
- Source :
- Genome. 31:662-667
- Publication Year :
- 1989
- Publisher :
- Canadian Science Publishing, 1989.
-
Abstract
- Human T-cell leukemia virus type 1 (HTLV-1) has two trans-acting regulator genes, tax and rex, in the pX region. The tax gene is a trans-acting transcriptional activator of the long terminal repeat (LTR) and also of the cellular gene for IL-2Rα. The latter seems to explain initiation of abnormal growth of HTLV-1 infected cells. The rex gene is a posttranscriptional regulator accumulating gag and env mRNA and also indirectly suppressing the transcription. The regulation requires two cis-acting elements, the LTR sequence at the 3′ terminus and 5′ splice signal, suggesting a novel mechanism of RNA processing in the nucleus. These two trans-activator genes are essential for efficient replication of HTLV-1 and also explain its poor replication competence and tendency to be latent in vivo.Key words: HTLV-1, trans-activation, posttranscriptional regulation, RNA splicing.
- Subjects :
- Gene Expression Regulation, Viral
Transcriptional Activation
RNA Splicing
viruses
Retroviridae Proteins, Oncogenic
Retroviridae Proteins
Regulator
Biology
Virus Replication
Cell Line
Transcription (biology)
Gene expression
Genetics
Animals
Humans
Leukemia-Lymphoma, Adult T-Cell
Molecular Biology
Gene
Regulator gene
Human T-lymphotropic virus 1
Messenger RNA
Gene Expression Regulation, Leukemic
Receptors, Interleukin-2
Gene Products, tax
General Medicine
Long terminal repeat
Rats
RNA splicing
Trans-Activators
Transcription Factors
Biotechnology
Subjects
Details
- ISSN :
- 14803321 and 08312796
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Genome
- Accession number :
- edsair.doi.dedup.....57df218ae5c32c1fb599789c056134b9