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Enhanced processing of APP induced by IL-1 beta can be reduced by indomethacin and nordihydroguaiaretic acid
- Source :
- Biochemical and biophysical research communications. 208(2)
- Publication Year :
- 1995
-
Abstract
- Abnormal processing of the amyloid precursor protein (APP) is thought to contribute to the formation of amyloid plaques in Alzheimer's disease. Several studies suggest that inflammation, and possibly the cytokines released during the inflammatory process, may participate in the plaque formation. We have utilized a cell culture system to examine the effects of the cytokine interleukin-1 beta (IL-1 beta) on the processing of APP. We present data to show that IL-1 beta increases the maturation of APP and causes enhanced processing of the full length APP isoforms. In addition, as reported previously in HUVEC cells, IL-1 beta increases the secretion of APP in PC12 cells. Indomethacin and NDGA, reported inhibitors of the cyclooxygenase and lipoxygenase pathways, respectively, block these effects, suggesting the involvement of prostaglandins and leukotrienes in IL-1 beta mediated APP processing.
- Subjects :
- medicine.medical_specialty
Amyloid
Prions
medicine.medical_treatment
Indomethacin
Biophysics
Inflammation
Pharmacology
In Vitro Techniques
Biochemistry
PC12 Cells
Lipoxygenase
chemistry.chemical_compound
Internal medicine
mental disorders
medicine
Amyloid precursor protein
Animals
Masoprocol
Secretion
Protein Precursors
Molecular Biology
biology
Cell Biology
Rats
Nordihydroguaiaretic acid
Endocrinology
Cytokine
chemistry
Cell culture
biology.protein
Cyclooxygenase
medicine.symptom
Protein Processing, Post-Translational
Interleukin-1
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 208
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Biochemical and biophysical research communications
- Accession number :
- edsair.doi.dedup.....57e34d9dbb14fbb7ff501606df707982