Back to Search
Start Over
Effects of bioactive peptides encrypted in whey-, soy- and rice protein on local and systemic angiotensin-converting enzyme activity
- Source :
- Journal of Functional Foods, Vol 28, Iss, Pp 299-305 (2017)
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- The renin-angiotensin system (RAS) is one of the main control systems of arterial blood pressure. Here, key player is the angiotensin converting enzyme (ACE). Inhibition of ACE is a standard therapy to lower elevated blood pressure. This study aimed to determine the ACE-inhibitory activity of tryptophan- and tyrosine-containing peptide mixes, based on hydrolysates of whey-, soy- and rice-protein. Effects on circulating and tissue ACE were investigated. IC50 values range from 16.60 ± 2.59 mg/l to 282.04 ± 18.51 mg/l, depending on the peptide mix and the ACE-system. Strongest ACE-inhibition is generally obtained with whey peptide mix characterized by a high fraction of isoleucine-tryptophan. Good inhibitory potential was obtained for plasma and tissue ACE. Thus, the use of whey peptide mix and isoleucine-tryptophan, respectively, appears to deserve further studies as innovative food additives with the potential to delay or even prevent RAS-related hypertension and subsequent deterioration of vessel structure and function.
- Subjects :
- 0301 basic medicine
Arterial hypertension
Whey protein
food.ingredient
Rice protein
Medicine (miscellaneous)
Peptide
030204 cardiovascular system & hematology
Hydrolysate
03 medical and health sciences
0302 clinical medicine
food
TX341-641
Food science
Soy protein
Bioactive peptides
chemistry.chemical_classification
Nutrition and Dietetics
biology
Chemistry
Nutrition. Foods and food supply
Food additive
Tryptophan
Angiotensin-converting enzyme
030104 developmental biology
biology.protein
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....57e59bc79bd991a83cb044258995c844