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U-shaped relationship between serum uric acid levels and intrarenal hemodynamic parameters in healthy subjects

Authors :
Eiji Ishimura
Akihiro Tsuda
Hideki Uedono
Masanori Emoto
Junji Uchida
Katsuhito Mori
Shinya Nakatani
Masaaki Inaba
Masafumi Kurajoh
Tatsuya Nakatani
Source :
American Journal of Physiology-Renal Physiology. 312:F992-F997
Publication Year :
2017
Publisher :
American Physiological Society, 2017.

Abstract

Hyperuricemia has been reported to affect renal hemodynamics. In a recent study, both low and high levels of serum uric acid (SUA) were found to be associated with loss of kidney function. The goal of this study was to evaluate the relationship between SUA levels and intrarenal hemodynamic parameters in healthy subjects, using plasma clearance of para-aminohippurate (CPAH) and inulin (Cin). Renal and glomerular hemodynamics were evaluated by simultaneous measurements of CPAHand Cinin 48 healthy subjects (54.6 ± 13.4 yr). Intrarenal hemodynamic parameters, including efferent and afferent (Ra) arteriolar resistance, were calculated using Gómez’s formulas. Relationships of SUA levels with these intrarenal hemodynamic parameters were examined. In quadratic regression analysis, SUA levels had a significant inverse U-shaped relationship with Cin( P < 0.0001, R2= 0.350) and CPAH( P = 0.0093, R2= 0.188) and a U-shaped relationship with Ra( P = 0.0011, R2= 0.262). In multiple regression analysis with normal (3.5–6.0 mg/dl) and mildly low or high (6.0 mg/dl) SUA levels entered as dummy variables of zero and one, respectively, mildly low or high SUA levels were significantly and independently associated with Ra(β = 0.230, P = 0.0403) after adjustment for several factors ( R2= 0.597, P < 0.0001). Both mild hyperuricemia and mild hypouricemia are significantly associated with increased Ra, although weakly. The increase in Rain subjects with mild hyperuricemia or hypouricemia may be related to renal hemodynamic abnormalities, possibly leading to a decline in renal function.

Details

ISSN :
15221466 and 1931857X
Volume :
312
Database :
OpenAIRE
Journal :
American Journal of Physiology-Renal Physiology
Accession number :
edsair.doi.dedup.....57f5a281be5ae3b9ce0e09f951d30790
Full Text :
https://doi.org/10.1152/ajprenal.00645.2016