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U-shaped relationship between serum uric acid levels and intrarenal hemodynamic parameters in healthy subjects
- Source :
- American Journal of Physiology-Renal Physiology. 312:F992-F997
- Publication Year :
- 2017
- Publisher :
- American Physiological Society, 2017.
-
Abstract
- Hyperuricemia has been reported to affect renal hemodynamics. In a recent study, both low and high levels of serum uric acid (SUA) were found to be associated with loss of kidney function. The goal of this study was to evaluate the relationship between SUA levels and intrarenal hemodynamic parameters in healthy subjects, using plasma clearance of para-aminohippurate (CPAH) and inulin (Cin). Renal and glomerular hemodynamics were evaluated by simultaneous measurements of CPAHand Cinin 48 healthy subjects (54.6 ± 13.4 yr). Intrarenal hemodynamic parameters, including efferent and afferent (Ra) arteriolar resistance, were calculated using Gómez’s formulas. Relationships of SUA levels with these intrarenal hemodynamic parameters were examined. In quadratic regression analysis, SUA levels had a significant inverse U-shaped relationship with Cin( P < 0.0001, R2= 0.350) and CPAH( P = 0.0093, R2= 0.188) and a U-shaped relationship with Ra( P = 0.0011, R2= 0.262). In multiple regression analysis with normal (3.5–6.0 mg/dl) and mildly low or high (6.0 mg/dl) SUA levels entered as dummy variables of zero and one, respectively, mildly low or high SUA levels were significantly and independently associated with Ra(β = 0.230, P = 0.0403) after adjustment for several factors ( R2= 0.597, P < 0.0001). Both mild hyperuricemia and mild hypouricemia are significantly associated with increased Ra, although weakly. The increase in Rain subjects with mild hyperuricemia or hypouricemia may be related to renal hemodynamic abnormalities, possibly leading to a decline in renal function.
- Subjects :
- renal hemodynamics
Adult
Male
medicine.medical_specialty
Renal Plasma Flow
Physiology
030232 urology & nephrology
Hemodynamics
Renal function
Hyperuricemia
030204 cardiovascular system & hematology
urologic and male genital diseases
Kidney
inulin clearance
Models, Biological
Renal Circulation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
イヌリンクリアランス
Humans
Renal hemodynamics
Infusions, Intravenous
Aged
Inulin Clearance
business.industry
Serum uric acid
Inulin
Healthy subjects
nutritional and metabolic diseases
para-aminohippurate clearance
Middle Aged
medicine.disease
Healthy Volunteers
Uric Acid
Endocrinology
chemistry
Regression Analysis
Uric acid
Female
p-Aminohippuric Acid
business
Biomarkers
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 15221466 and 1931857X
- Volume :
- 312
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Renal Physiology
- Accession number :
- edsair.doi.dedup.....57f5a281be5ae3b9ce0e09f951d30790
- Full Text :
- https://doi.org/10.1152/ajprenal.00645.2016