Back to Search
Start Over
Antigenic variations of recent street rabies virus
- Source :
- Emerging Microbes & Infections
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- The genetic and/or antigenic differences between street rabies virus (RABV) and vaccine strains could potentially affect effectiveness of rabies vaccines. As such, it is important to continue monitoring the glycoprotein (G) of the street isolates. All RABVG sequences in public database were retrieved and analysed. Using a pseudovirus system, we investigated 99 naturally occurring mutants for their reactivities to well-characterized neutralizing monoclonal antibodies (mAbs) and vaccine-induced antisera. A divergence in G sequences was found between vaccine strains and recent street isolates, with mutants demonstrating resistance to neutralizing mAbs and vaccine-induced antibodies. Moreover, antigenic variants were observed in a wide range of animal hosts and geographic locations, with most of them emerging since 2010. As the number of antigenic variants has increased in recent years, close monitoring on street isolates should be strengthened.
- Subjects :
- glycoprotein
0301 basic medicine
Rabies
Epidemiology
medicine.drug_class
Guinea Pigs
030106 microbiology
Immunology
Biology
Antibodies, Viral
medicine.disease_cause
Monoclonal antibody
Microbiology
Article
Neutralization
03 medical and health sciences
Vaccine strain
Viral Envelope Proteins
Antigen
Neutralization Tests
vaccine
Virology
Drug Discovery
medicine
Animals
Humans
chemistry.chemical_classification
Rabies virus
General Medicine
neutralization
medicine.disease
Antibodies, Neutralizing
Antigenic Variation
030104 developmental biology
Infectious Diseases
Rabies Vaccines
chemistry
monoclonal antibody
Female
Parasitology
Glycoprotein
Subjects
Details
- ISSN :
- 22221751
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Emerging Microbes & Infections
- Accession number :
- edsair.doi.dedup.....580bbb17913799d4df66de31459fa886