Back to Search
Start Over
N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase
- Source :
- Bioorganic & Medicinal Chemistry Letters. 20:1589-1592
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- A series of N1-alkyl pyrimidinediones were designed, synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Our efforts identified compound 10b, which represents the lead compound in this series with pharmacokinetics and antiviral potency that may support once-daily dosing.
- Subjects :
- Anti-HIV Agents
Clinical Biochemistry
Human immunodeficiency virus (HIV)
Pharmaceutical Science
Pyrimidinones
Pharmacology
Crystallography, X-Ray
medicine.disease_cause
Biochemistry
Structure-Activity Relationship
chemistry.chemical_compound
Dogs
Pharmacokinetics
Microsomes
Drug Discovery
Pyrimidinedione
medicine
Animals
Humans
Potency
Molecular Biology
Alkyl
chemistry.chemical_classification
Binding Sites
Organic Chemistry
virus diseases
HIV Reverse Transcriptase
Reverse transcriptase
chemistry
Reverse Transcriptase Inhibitors
Molecular Medicine
Nucleoside
Lead compound
Thymine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....580eae4286c53b40bb72e6ab7e081863
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.01.085