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The enhanced plasma levels of soluble tumor necrosis factor receptors (sTNF-R1; sTNF-R2) and interleukin-10 (IL-10) in patients suffering from chronic heart failure are reversed in patients treated with beta-adrenoceptor antagonist
- Source :
- Autonomic and Autacoid Pharmacology. 22:83-92
- Publication Year :
- 2002
- Publisher :
- Wiley, 2002.
-
Abstract
- Summary 1 Cytokines may parallel or regulate the beneficial effects of β-adrenoceptor antagonist treatment observed in chronic heart failure (CHF) patients. Therefore, this study was performed in order to investigate alterations of cytokine levels in β-blocker-treated patients suffering from CHF. 2 We investigated plasma cytokine levels in eight healthy controls and 12 CHF patients. The patients were treated with standard medication (CHFstd) or with standard medication and additional β1-blocker metoprolol (CHFmet). Interleukin-(IL)-1α, IL-1β, IL-1 receptor antagonist (IL-1ra), IL-2, IL-6, IL-8, IL-10, tumor necrosis factor-α (TNF), soluble TNF receptor type 1 (sTNF-R1), sTNF-R2, and sCD14 were measured by ELISA. 3 IL-1α and IL-1β were not detectable in any of the tested groups. IL-2, TNF, or sCD14 were not altered as compared with healthy control subjects. CHFstd patients expressed enhanced IL-1ra, IL-6, IL-8, IL-10, sTNF-R1 and sTNF-R2. In CHFmet patients IL-1ra, IL-6 and IL-8 remained at the same level. In contrast, sTNF-R1 levels were significantly reduced, although not to control, whereas the sTNF-R2 and IL-10 were reduced to control levels. 4 The cAMP levels of mononuclear cells – recalculated for the patients included in this study from previous work [Werner et al. (2001). Basic Res. Cardiol., 96, 290]– correlated inversely with the sTNF-R2 data (Pearson, r=−0.46; P=0.041; Spearman, r=−0.64, P=0.002). 5 The present data indicate an interaction of the neurohumoral and the cytokine system in CHF patients at the cAMP level. Thus, measurement and correlation of sTNF-R2 and cAMP may provide a tool useful during investigation of β-blocker therapy.
- Subjects :
- Male
medicine.medical_specialty
medicine.drug_class
medicine.medical_treatment
Adrenergic beta-Antagonists
Receptors, Tumor Necrosis Factor
Statistics, Nonparametric
Antigens, CD
Internal medicine
Humans
Receptors, Tumor Necrosis Factor, Type II
Medicine
Receptor
Aged
Metoprolol
Heart Failure
Pharmacology
Analysis of Variance
business.industry
Antagonist
Middle Aged
Receptor antagonist
medicine.disease
Adrenergic beta-1 Receptor Antagonists
Interleukin-10
Interleukin 10
Cytokine
Endocrinology
Receptors, Tumor Necrosis Factor, Type I
Heart failure
Female
Tumor necrosis factor alpha
business
medicine.drug
Subjects
Details
- ISSN :
- 14748673 and 14748665
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Autonomic and Autacoid Pharmacology
- Accession number :
- edsair.doi.dedup.....581d164f3547373480b01a1d4cb78fb5