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An Ultra-Deep Targeted Sequencing Gene Panel Improves the Prognostic Stratification of Patients With Advanced Oral Cavity Squamous Cell Carcinoma
- Source :
- Medicine
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- An improved prognostic stratification of patients with oral cavity squamous cell carcinoma (OSCC) and pathologically positive (pN+) nodes is urgently needed. Here, we sought to examine whether an ultra-deep targeted sequencing (UDT-Seq) gene panel may improve the prognostic stratification in this patient group. A mutation-based signature affecting 10 genes (including genetic mutations in 6 oncogenes and 4 tumor suppressor genes) was devised to predict disease-free survival (DFS) in 345 primary tumor specimens obtained from pN+ OSCC patients. Of the 345 patients, 144 were extracapsular spread (ECS)-negative and 201 were ECS-positive. The 5-year locoregional control, distant metastases, disease-free, disease-specific, and overall survival (OS) rates served as outcome measures. The UDT-Seq panel was an independent risk factor (RF) for 5-year locoregional control (P = 0.0067), distant metastases (P = 0.0001), DFS (P
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Scoring system
Observational Study
Disease
Prognostic stratification
03 medical and health sciences
0302 clinical medicine
Risk Factors
Gene panel
Internal medicine
Humans
Medicine
Genes, Tumor Suppressor
Oral Cavity Squamous Cell Carcinoma
Risk factor
Patient group
Aged
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
business.industry
Gene Expression Profiling
High-Throughput Nucleotide Sequencing
Oncogenes
General Medicine
Middle Aged
Prognosis
medicine.disease
Survival Analysis
Primary tumor
Surgery
Survival Rate
stomatognathic diseases
030104 developmental biology
030220 oncology & carcinogenesis
Mutation
Carcinoma, Squamous Cell
Female
Mouth Neoplasms
business
Research Article
Subjects
Details
- ISSN :
- 00257974
- Volume :
- 95
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....582f1ec9c8e563e92291fe2bef416f4b