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Biomedical Applications Of Polymeric Cryogels
- Source :
- Applied Sciences, Vol 9, Iss 3, p 553 (2019)
- Publication Year :
- 2019
-
Abstract
- The application of interconnected supermacroporous cryogels as support matrices for the purification, separation and immobilization of whole cells and different biological macromolecules has been well reported in literature. Cryogels have advantages over traditional gel carriers in the field of biochromatography and related biomedical applications. These matrices nearly mimic the three-dimensional structure of native tissue extracellular matrix. In addition, mechanical, osmotic and chemical stability of cryogels make them attractive polymeric materials for the construction of scaffolds in tissue engineering applications and in vitro cell culture, separation materials for many different processes such as immobilization of biomolecules, capturing of target molecules, and controlled drug delivery. The low mass transfer resistance of cryogel matrices makes them useful in chromatographic applications with the immobilization of different affinity ligands to these materials. Cryogels have been introduced as gel matrices prepared using partially frozen monomer or polymer solutions at temperature below zero. These materials can be produced with different shapes and are of interest in the therapeutic area. This review highlights the recent advances in cryogelation technologies by emphasizing their biomedical applications to supply an overview of their rising stars day to day.
- Subjects :
- Scaffold
separation
Materials science
purification
0206 medical engineering
Nanotechnology
02 engineering and technology
scaffold
lcsh:Technology
lcsh:Chemistry
chemistry.chemical_compound
bioreactor
Tissue engineering
General Materials Science
lcsh:QH301-705.5
Instrumentation
Fluid Flow and Transfer Processes
chemistry.chemical_classification
lcsh:T
Process Chemistry and Technology
Biomolecule
General Engineering
Polymer
021001 nanoscience & nanotechnology
020601 biomedical engineering
lcsh:QC1-999
Computer Science Applications
Monomer
lcsh:Biology (General)
lcsh:QD1-999
chemistry
lcsh:TA1-2040
supermacroporous cryogel
tissue engineering
Drug delivery
cell separation
lcsh:Engineering (General). Civil engineering (General)
0210 nano-technology
lcsh:Physics
In vitro cell culture
Macromolecule
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Applied Sciences, Vol 9, Iss 3, p 553 (2019)
- Accession number :
- edsair.doi.dedup.....5838766bab8c609e35e5a20030db2ace