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Detection of the association between a deletion polymorphism in the gene encoding angiotensin I-converting enzyme and advanced diabetic retinopathy
- Source :
- Diabetes research and clinical practice. 50(3)
- Publication Year :
- 2000
-
Abstract
- We investigated the relationship between advanced diabetic retinopathy (ADR) and an angiotensin-converting enzyme (ACE) gene polymorphism in subjects with type 2 diabetes and ADR, pre-proliferative (PrePDR) or proliferative diabetic retinopathy (PDR) without overt nephropathy. Polymerase chain reactions were used to detect insertion/deletion (I/D) polymorphisms of the ACE gene. There was no difference in the frequency of II, ID, or DD genotypes, or of I and D alleles among subjects with type 2 diabetes without diabetic retinopathy (NDR) or with simple diabetic retinopathy (SDR) and non-diabetic controls. There was also no difference in the frequency of ACE genotypes among subjects with type 2 diabetes with NDR, or SDR and ADR. However, the frequency of the ACE DD genotype in ADR was significantly higher than that in controls ( χ 2 =6.64, P =0.036). On the other hand, the frequency of the D allele in ADR was significantly higher than that in controls ( χ 2 =6.33, P =0.012), NDR ( χ 2 =4.18, P =0.041) and SDR ( χ 2 =4.89, P =0.027), respectively. These results indicate a significant relationship between the presence of the D allele polymorphism in the ACE gene and ADR in Japanese subjects with type 2 diabetes and no overt nephropathy.
- Subjects :
- Male
medicine.medical_specialty
Genotype
Endocrinology, Diabetes and Metabolism
Blood Pressure
Type 2 diabetes
Peptidyl-Dipeptidase A
Polymerase Chain Reaction
Endocrinology
Reference Values
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
Albuminuria
Humans
Allele
Sequence Deletion
Diabetic Retinopathy
Polymorphism, Genetic
biology
business.industry
Angiotensin-converting enzyme
General Medicine
Diabetic retinopathy
Middle Aged
medicine.disease
Diabetes Mellitus, Type 2
biology.protein
DNA Transposable Elements
Disease Progression
Female
Gene polymorphism
business
Retinopathy
Subjects
Details
- ISSN :
- 01688227
- Volume :
- 50
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Diabetes research and clinical practice
- Accession number :
- edsair.doi.dedup.....584e03cb862c39c10359ca89a39a037b