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Joint symptoms in patients on bupropion therapy
- Source :
- Joint Bone Spine. 71:583-585
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- Objective. – To describe joint symptoms related to bupropion therapy. Methods. – We retrospectively reviewed adverse events in bupropion-treated patients reported to the Bourgogne Drug Surveillance Center, France, between October 2001 and December 2002. Joint symptoms classified by the causality assessment as related to bupropion were identified and examined. Results. – Four cases were found. Three patients had semi-delayed hypersensitivity reactions resembling serum sickness, manifesting as urticaria and arthralgia with or without a fever. The remaining patient had an unusual presentation consisting in acute monoarthritis of the wrist that started a few days after bupropion initiation. Conclusion. – Hypersensitivity reactions to bupropion are fairly common and include rare cases of serum sickness-like reaction. Urticaria and incapacitating arthralgia are at the forefront of the clinical picture and may require a brief period of inpatient care. Antihistamines are the treatment of choice. Other manifestations such as acute monoarthritis might occur, although this awaits confirmation as we identified a single case.
- Subjects :
- Adult
Male
Bupropion therapy
medicine.medical_specialty
Arthritis
Serum Sickness
Rheumatology
mental disorders
medicine
Monoarthritis
Humans
In patient
Adverse effect
Bupropion
business.industry
Middle Aged
medicine.disease
Dermatology
Anesthesia
Serum sickness
Antidepressive Agents, Second-Generation
Female
Joints
business
medicine.drug
Subjects
Details
- ISSN :
- 1297319X
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Joint Bone Spine
- Accession number :
- edsair.doi.dedup.....584f1d88f1e1d0502588c78590b3231e