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Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients
- Source :
- Multiple Sclerosis Journal. 22:1883-1887
- Publication Year :
- 2016
- Publisher :
- SAGE Publications, 2016.
-
Abstract
- Background: No molecular marker can monitor disease progression and treatment efficacy in multiple sclerosis (MS). Circulating microparticles represent a potential snapshot of disease activity at the blood brain barrier. Objectives and methods: To profile plasma microparticles by flow cytometry in MS and determine how fingolimod could impact endothelial microparticles production. Results: In non-treated MS patients compared to healthy and fingolimod-treated patients, endothelial microparticles were higher, while B-cell-microparticle numbers were lower. Fingolimod dramatically reduced tumour necrosis factor (TNF)-induced endothelial microparticle release in vitro. Conclusion: Fingolimod restored dysregulated endothelial and B-cell-microparticle numbers, which could serve as a biomarker in MS.
- Subjects :
- Adult
Male
0301 basic medicine
Multiple Sclerosis
Pharmacology
Disease activity
03 medical and health sciences
0302 clinical medicine
Cell-Derived Microparticles
medicine
Humans
B cell
B-Lymphocytes
Neurology & Neurosurgery
Fingolimod Hydrochloride
business.industry
Multiple sclerosis
Disease progression
Endothelial Cells
Plasma levels
Middle Aged
medicine.disease
Fingolimod
Treatment efficacy
Vascular endothelium
030104 developmental biology
medicine.anatomical_structure
Neurology
Immunology
Female
Endothelium, Vascular
Neurology (clinical)
business
Immunosuppressive Agents
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 14770970 and 13524585
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Multiple Sclerosis Journal
- Accession number :
- edsair.doi.dedup.....586e66cc2d2d379cdf487841144f9abf