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Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part II: curcumin derivatives in cancer and neurodegeneration
- Source :
- Expert Opinion on Therapeutic Patents. 27:953-965
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- Introduction: Curcumin, the main bioactive compound found in the rhizome of Curcuma longa L., is considered a âprivileged structureâ, due to its ability to modulate different signaling pathways involved in the pathogenesis of several diseases. Unfortunately, its poor pharmacodynamic and pharmacokinetic properties, mainly related to chemical instability, low solubility and rapid metabolism, greatly reduce its therapeutic potential. In the last years a number of derivatives were developed and patented, aimed both at improving its multifaceted biological profile and overcoming its undesired effects. Areas covered: This review summarizes the patent literature of the last five years dealing with synthetic curcumin-related compounds in cancer and neurodegeneration, properly designed in order to avoid the so-called âdark side of curcuminâ, and to take advantage of the beneficial properties of this molecule, worth to be further exploited to obtain effective therapeutics. Expert opinion: Due to the synergistic binding to several networked targets, curcumin turned out to be suitable for polypharmacological approaches, and its âprivileged structureâ could also provide the key scaffold to develop novel multipotent drugs useful for treating multifactiorial pathologic conditions such as cancer and neurodegeneration.
- Subjects :
- 0301 basic medicine
natural product
Curcumin
Patent literature
Antineoplastic Agents
Biology
Pharmacology
Drug synergism
privileged structure
Antineoplastic Agent
Patents as Topic
03 medical and health sciences
chemistry.chemical_compound
Curcuma
0302 clinical medicine
Biological profile
Neoplasms
Drug Discovery
medicine
Animals
Humans
cancer
Neurodegenerative Disease
Animal
Drug Discovery3003 Pharmaceutical Science
Neurodegeneration
neurodegeneration
Cancer
Neurodegenerative Diseases
Drug Synergism
General Medicine
medicine.disease
Bioactive compound
Chemical instability
030104 developmental biology
Solubility
chemistry
Drug Design
Neoplasm
Azheimerâs disease
030217 neurology & neurosurgery
Human
Subjects
Details
- ISSN :
- 17447674 and 13543776
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Expert Opinion on Therapeutic Patents
- Accession number :
- edsair.doi.dedup.....586fde0d14ccf8f92e56c5c92b1eeeec