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An estimate of amyotrophic lateral sclerosis heritability using twin data
- Source :
- Journal of Neurology, Neurosurgery, and Psychiatry
- Publication Year :
- 2010
- Publisher :
- BMJ, 2010.
-
Abstract
- Background Causative gene mutations have been identified in about 2% of those with amyotrophic lateral sclerosis (ALS), often, but not always, when there is a strong family history. There is an assumption that there is a genetic component to all ALS, but genome-wide association studies have yet to produce a robustly replicated result. A definitive estimate of ALS heritability is therefore required to determine whether ongoing efforts to find susceptibility genes are worth while. Methods The authors performed two twin studies, one population- and one clinic-based. The authors used structural equation modelling to perform a meta-analysis of data from these studies and an existing twin study to estimate ALS heritability, and identified 171 twin pairs in which at least one twin had ALS. Results and discussion Five monozygotic twin pairs were concordant-affected, and 44 discordant-affected. No dizygotic twin pairs were concordant-affected, and 122 discordant-affected. The heritability of sporadic ALS was estimated as 0.61 (0.38 to 0.78) with the unshared environmental component 0.39 (0.22 to 0.62). ALS has a high heritability, and efforts to find causative genes should continue.
- Subjects :
- amyotrophic lateral sclerosis
Genotype
Dizygotic twin
Population
Monozygotic twin
Penetrance
heritability
frontotemporal dementia
Developmental psychology
03 medical and health sciences
0302 clinical medicine
Diseases in Twins
Twins, Dizygotic
Humans
Medicine
genetics
Genetic Predisposition to Disease
Registries
Amyotrophic lateral sclerosis
10. No inequality
education
030304 developmental biology
Genetic association
Sweden
Genetics
0303 health sciences
education.field_of_study
Models, Genetic
business.industry
Twin study
Epistasis, Genetic
Twins, Monozygotic
Heritability
medicine.disease
Twin Studies as Topic
United Kingdom
Psychiatry and Mental health
motor neuron disease
Surgery
Neurology (clinical)
ALS
business
030217 neurology & neurosurgery
Research Paper
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 00223050
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Accession number :
- edsair.doi.dedup.....587588d044d4af3a2d6d6e9e71f185b5