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Neurological sequelae in patients with covid-19: A histopathological perspective
- Source :
- International Journal of Environmental Research and Public Health, Vol 18, Iss 1415, p 1415 (2021), International Journal of Environmental Research and Public Health
- Publication Year :
- 2021
-
Abstract
- Background: Neuroinvasive properties of SARS-CoV-2 have allowed the hypothesis of several pathogenic mechanisms related to acute and chronic neurological sequelae. However, neuropathological correlates have been poorly systematically investigated, being retrieved from reports of single case or limited case series still. Methods: A PubMed search was carried out to review all publications on autopsy in subjects with “COronaVIrus Disease-19” (COVID-19). Among them, we focused on histological findings of the brain, which were compared with those from the authors’ autoptic studies performed in some COVID-19 patients. Results: Only seven studies reported histological evidence of brain pathology in patients deceased for COVID-19, including three with reverse transcription–quantitative polymerase chain reaction evidence of viral infection. All these studies, in line with our experience, showed vascular-related and infection-related secondary inflammatory tissue damage due to an abnormal immune response. It is still unclear, however, whether these findings are the effect of a direct viral pathology or rather reflect a non-specific consequence of cardiovascular and pulmonary disease on the brain. Conclusions: Notwithstanding the limited evidence available and the heterogeneity of the studies, we provide a preliminary description of the relationship between SARS-CoV-2 and brain sequelae. Systematic autoptic investigations are needed for accurate detection and adequate management of these patients.
- Subjects :
- medicine.medical_specialty
Pathology
Coronavirus disease 2019 (COVID-19)
Health, Toxicology and Mutagenesis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
lcsh:Medicine
Histopathology
Autopsy
Review
Neuropathology
medicine.disease_cause
Neuroinvasion
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Pathogenesi
medicine
Humans
In patient
long-term prognosis
030212 general & internal medicine
Coronavirus
Outcome
business.industry
SARS-CoV-2
pathogenesis
lcsh:R
Public Health, Environmental and Occupational Health
COVID-19
Long-term prognosi
Brain
Nervous System Diseases
business
030217 neurology & neurosurgery
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health, Vol 18, Iss 1415, p 1415 (2021), International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....5885bd5826dcddb272d76a400a86fd49