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Regenerative responses of rabbit corneal endothelial cells to stimulation by fibroblast growth factor 1 (FGF1) derivatives, TTHX1001 and TTHX1114

Authors :
Jessica Weant
David D. Eveleth
Amuthakannan Subramaniam
Jennifer Jenkins-Eveleth
Michael Blaber
Ling Li
David M. Ornitz
Asaf Alimardanov
Trevor Broadt
Hui Dong
Vinay Vyas
Xiaoyi Yang
Ralph A. Bradshaw
Source :
Growth Factors. 39:14-27
Publication Year :
2021
Publisher :
Informa UK Limited, 2021.

Abstract

Utilising rabbit corneal endothelial cells (CEC) in three different paradigms, two human FGF1 derivatives (TTHX1001 and TTHX1114), engineered to exhibit greater stability, were tested as proliferative agents. Primary CECs and mouse NIH 3T3 cells treated with the two FGF1 derivatives showed equivalent EC

Details

ISSN :
10292292 and 08977194
Volume :
39
Database :
OpenAIRE
Journal :
Growth Factors
Accession number :
edsair.doi.dedup.....58a02a16950f215d35b6e51589736f2c
Full Text :
https://doi.org/10.1080/08977194.2021.2012468