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Notoginsenoside R1 inhibits vascular smooth muscle cell proliferation, migration and neointimal hyperplasia through PI3K/Akt signaling
- Source :
- Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018), Scientific Reports
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- Restenosis caused by neointimal hyperplasia significantly decreases long-term efficacy of percutaneous transluminal angioplasty (PTA), stenting, and by-pass surgery for managing coronary and peripheral arterial diseases. A major cause of pathological neointima formation is abnormal vascular smooth muscle cell (VSMC) proliferation and migration. Notoginsenoside R1 (NGR1) is a novel saponin that is derived from Panax notoginseng and has reported cardioprotective, neuroprotective and anti-inflammatory effects. However, its role in modulating VSMC neointima formation remains unexplored. Herein, we report that NGR1 inhibits serum-induced VSMC proliferation and migration by regulating VSMC actin cytoskeleton dynamics. Using a mouse femoral artery endothelium denudation model, we further demonstrate that systemic administration of NGR1 had a potent therapeutic effect in mice, significantly reducing neointimal hyperplasia following acute vessel injury. Mechanistically, we show that NGR1’s mode of action is through inhibiting the activation of phosphatidylinositol 3-kinase (PI3K)/Akt signaling. Taken together, this study identified NGR1 as a potential therapeutic agent for combating restenosis after PTA in cardiovascular diseases.
- Subjects :
- Male
0301 basic medicine
Neointima
Vascular smooth muscle
Ginsenosides
Myocytes, Smooth Muscle
lcsh:Medicine
Article
Muscle, Smooth, Vascular
Phosphatidylinositol 3-Kinases
03 medical and health sciences
Restenosis
Cell Movement
Animals
Humans
Medicine
Myocyte
lcsh:Science
Protein kinase B
Cells, Cultured
PI3K/AKT/mTOR pathway
Cell Proliferation
Neointimal hyperplasia
Hyperplasia
Multidisciplinary
business.industry
lcsh:R
medicine.disease
Actin cytoskeleton
3. Good health
Disease Models, Animal
030104 developmental biology
Cancer research
cardiovascular system
lcsh:Q
business
Proto-Oncogene Proteins c-akt
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....5908967ee4faec61954f62211bf7b5b5
- Full Text :
- https://doi.org/10.1038/s41598-018-25874-y