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Clinical trial participation of patients with glioblastoma at The University of Texas MD Anderson Cancer Center
- Source :
- European Journal of Cancer. 112:83-93
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Background It is estimated only 8–11% of patients with glioblastoma (GBM) enrol in clinical trials, limiting treatment development. We analysed the clinical and demographic features of patients with GBM enroled in clinical trials at the University of Texas MD Anderson Cancer Center (MDACC). Methods We reviewed the records of adult patients treated for primary GBM between 2007 and 2012 at the MDACC. A total of 755 patients were identified: 133 were deemed non-eligible, 111 were deemed trial eligible but received standard care and 511 participated in a clinical trial (311 for newly diagnosed glioblastoma [nGBM] and 200 for recurrent glioblastoma [rGBM]). Population characteristics were analysed using descriptive statistics, and survival end-points were evaluated with the Kaplan–Meier method. Results The median age of clinical trial participants and trial eligible patients was 53.2 years (standard deviation 12.1). Most patients (49.4%) were enroled in a clinical trial protocol for nGBM. The majority of nGBM trial participants were male patients (65.1%), white (86.3%), married (84.4%) and in state (59.9%). Employment status, education, symptoms, tumour location, performance status, extent of resection and treatment facility differed between nGBM trial participants and non-participants. Patients who were eligible but did not enrol tended to be older, have worse performance status and live farther away from the MDACC. Conclusion Numerous disease and demographic barriers exist in trial enrolment in patients with GBM. This study highlights some of these obstacles, which require attention to improve patient enrolment to clinical trials. Patient and physician engagement in novel therapeutic strategies is essential to improving outcomes in this disease.
- Subjects :
- Male
0301 basic medicine
Cancer Research
medicine.medical_specialty
Universities
Population
Kaplan-Meier Estimate
Disease
03 medical and health sciences
0302 clinical medicine
Internal medicine
Humans
Medicine
In patient
education
Clinical Trials as Topic
education.field_of_study
Performance status
Brain Neoplasms
business.industry
Treatment development
Cancer
Middle Aged
medicine.disease
Texas
Clinical trial
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Female
Neoplasm Recurrence, Local
Glioblastoma
business
Subjects
Details
- ISSN :
- 09598049
- Volume :
- 112
- Database :
- OpenAIRE
- Journal :
- European Journal of Cancer
- Accession number :
- edsair.doi.dedup.....590ba5a6de940a78064880eed1e065a6