(1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents

Authors :: Arnaldo Fravolini
Fausto Schiaffella
Violetta Cecchetti
Oriana Tabarrini
Source :: Bioorganic & Medicinal Chemistry Letters. 10:465-468
Publication Year :: 2000
Publisher :: Elsevier BV, 2000.
Abstract: A series of compounds having a piperazine moiety variously linked to the benzothiazine nucleus were synthesized and evaluated for their in vitro alpha-adrenoceptor affinity by radioligand receptor binding assays. Some compounds bearing a oxyalkyl-(2-methoxyphenyl)piperazine side chain were good alpha1-adrenoreceptor ligands.

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