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Prognostic significance of Spinster homolog gene family in acute myeloid leukemia
- Source :
- Journal of Breast Cancer, 11(15), 4581-4588. IVYSPRING INT PUBL, Journal of Cancer
- Publication Year :
- 2020
- Publisher :
- IVYSPRING INT PUBL, 2020.
-
Abstract
- Acute myeloid leukemia (AML) is a clonal and heterogeneous disease characterized by proliferation of immature myeloid cells, with impaired differentiation and maturation. Spinster homolog (SPNS) is a widely distributed transmembrane transporter, which assists sphingolipids in playing their roles through the cell membrane. However, the expression and clinical implication of the SPNS family has not been investigated in AML. From the Cancer Genome Atlas database, a total of 155 AML patients with complete clinical characteristics and SPNS1-3 expression data were contained in our study. In patients who received chemotherapy only, high expressions of SPNS2 and SPNS3 had adverse effects on event-free survival (EFS) and overall survival (OS) (all P<0.05). However, in the allogeneic hematopoietic stem cell transplantation (allo-HSCT) group, we only found a significant difference in OS between the high and low SPNS3 expression groups (P=0.001), while other SPNS members showed no effect on survival. Multivariate analysis indicated that high SPNS2 expression was an independent risk factor for both EFS and OS in chemotherapy patients. The results confirmed that high expression of SPNS2 and SPNS3 were poor prognostic factors, and the effect of SPNS2 can be neutralized by allo-HSCT.
- Subjects :
- 0301 basic medicine
SPNS2
SPNS1
medicine.medical_treatment
Disease
Hematopoietic stem cell transplantation
SPNS3
03 medical and health sciences
0302 clinical medicine
medicine
Gene family
Adverse effect
Chemotherapy
Acute myeloid leukemia
business.industry
TRANSPLANTATION
Myeloid leukemia
SPHINGOSINE-1-PHOSPHATE TRANSPORTER SPNS2
Prognosis
Sphingolipid
Transmembrane protein
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
CELLS
Cancer research
business
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 17386756 and 18379664
- Volume :
- 11
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Journal of Breast Cancer
- Accession number :
- edsair.doi.dedup.....592a8c4430f28c0038b50f447474f1cf