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Multiple bacterial topoisomerases: specialization or redundancy?
- Source :
- BioEssays : news and reviews in molecular, cellular and developmental biology. 15(7)
- Publication Year :
- 1993
-
Abstract
- In the past few years, two new DNA topoisomerases have been discovered in bacteria, bringing the total number of DNA topoisomerases in E. coli to four. Two classes of topoisomerases, type 1 and type 2, are distinguishable by their amino acid homology and their apparent reaction mechanism. Of the four E. coli topoisomerases, there are two type 1 and two type 2 enzymes. In eukaryotes, the existence of multiple type 1 and type 2 enzymes has also become apparent. The existence of these multiple enzymes provokes a question whose answer has both evolutionary and physiological implications: are these topoisomerases functionally redundant, or have they acquired sufficient specialization that they now perform unique biological reactions? In bacteria, there is evidence for both specialization and redundancy in the functions of topoisomerases.
- Subjects :
- DNA Topoisomerase IV
DNA, Bacterial
Salmonella typhimurium
Amino acid homology
Computational biology
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
Substrate Specificity
chemistry.chemical_compound
Bacterial Proteins
Specialization (functional)
Redundancy (engineering)
Escherichia coli
Gene
chemistry.chemical_classification
biology
DNA, Superhelical
Topoisomerase
biology.organism_classification
Isoenzymes
Enzyme
DNA Topoisomerases, Type II
Eukaryotic Cells
chemistry
DNA Topoisomerases, Type I
Genes, Bacterial
biology.protein
DNA, Circular
DNA
Bacteria
Subjects
Details
- ISSN :
- 02659247
- Volume :
- 15
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- BioEssays : news and reviews in molecular, cellular and developmental biology
- Accession number :
- edsair.doi.dedup.....59312f28e7fa456e268121b0f7f238f8