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Resting frontal EEG asymmetry in adolescents with major depression: Impact of disease state and comorbid anxiety disorder
- Source :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 129(12)
- Publication Year :
- 2018
-
Abstract
- Objective Greater relative right- than left-frontal cortical activity has been frequently found in adults with major depression (MD). As the few studies in adolescents with MD have been inconclusive, the aim of this study was to assess frontal alpha asymmetry (FAA) in an adolescent sample with MD whilst taking into account possible confounding variables such as disease state and comorbid anxiety disorder. Methods An 8-minute resting frontal EEG was assessed in 34 healthy controls (HCs), 16 adolescents with MD in remission without comorbid anxiety disorder (rMDa−), 22 adolescents with acute depression without comorbid anxiety disorder (MDa−), and 23 adolescents with acute depression and comorbid anxiety disorder (MDa+). Alpha power was analyzed over corresponding frontal Regions of Interests. Results Compared to HCs, MDa+ adolescents demonstrated more left- than right-sided EEG alpha power, indicating greater right-than left-frontal cortical activity. No other group differences emerged. Conclusions The results suggest that greater relative right-frontal cortical activity in adolescent MD is not a result of disease state but can be attributed to comorbid anxiety disorder. Significance Results suggest that FAA is not linked to adolescent depression per se and highlight the importance of considering comorbid disorders when examining asymmetry patterns in adolescent MD.
- Subjects :
- Male
Comorbid anxiety
Adolescent
Disease
Electroencephalography
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
Medicine
Humans
0501 psychology and cognitive sciences
Eeg asymmetry
Depression (differential diagnoses)
Depressive Disorder, Major
medicine.diagnostic_test
business.industry
05 social sciences
Confounding
Anxiety Disorders
Sensory Systems
Frontal Lobe
Alpha Rhythm
Neurology
Female
Neurology (clinical)
business
Alpha power
030217 neurology & neurosurgery
Eeg alpha
Clinical psychology
Subjects
Details
- ISSN :
- 18728952
- Volume :
- 129
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....593801c494f9777a6900133e4946a352