Back to Search Start Over

Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy:A nested study within a randomized placebo controlled trial

Authors :
Annina Elisabeth Büchi
Martin Feller
Seraina Netzer
Manuel R. Blum
Elena Gonzalez Rodriguez
Tinh-Hai Collet
Cinzia Del Giovane
Diana van Heemst
Terry Quinn
Patricia M. Kearney
Rudi G.J. Westendorp
Jacobijn Gussekloo
Simon P. Mooijaart
Didier Hans
Douglas C. Bauer
Nicolas Rodondi
Daniel Aeberli
Source :
Büchi, A E, Feller, M, Netzer, S, Blum, M R, Gonzalez Rodriguez, E, Collet, T-H, Del Giovane, C, van Heemst, D, Quinn, T, Kearney, P M, Westendorp, R G J, Gussekloo, J, Mooijaart, S P, Hans, D, Bauer, D C, Rodondi, N & Aeberli, D 2022, ' Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy : A nested study within a randomized placebo controlled trial ', Bone, vol. 161, 116404 . https://doi.org/10.1016/j.bone.2022.116404, Bone (2022) P. 116404, Bone, 161. ELSEVIER SCIENCE INC, Büchi, Annina Elisabeth; Feller, Martin; Netzer, Seraina; Blum, Manuel R; Rodriguez, Elena Gonzalez; Collet, Tinh-Hai; Del Giovane, Cinzia; van Heemst, Diana; Quinn, Terry; Kearney, Patricia M; Westendorp, Rudi G J; Gussekloo, Jacobijn; Mooijaart, Simon; Hans, Didier; Bauer, Douglas C; Rodondi, Nicolas; Aeberli, Daniel (2022). Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy: A nested study within a randomized placebo controlled trial. Bone, 161, p. 116404. Elsevier 10.1016/j.bone.2022.116404
Publication Year :
2022

Abstract

The effect of levothyroxine (LT4) therapy for subclinical hypothyroidism (SHypo) on appendicular bone geometry and volumetric density has so far not been studied. In a nested study within the randomized, placebocontrolled Thyroid Hormone Replacement for Subclinical Hypothyroidism (TRUST) trial, we assessed the effect of LT4 therapy on bone geometry as measured by peripheral quantitative computed tomography (pQCT). In the TRUST trial, community-dwelling adults aged >= 65 years with SHypo were randomized to LT4 with dose titration vs. placebo with mock titration. We analyzed data from participants enrolled at the TRUST site in Bern, Switzerland who had bone pQCT measured at baseline and at 1 to 2 years follow-up. The primary outcomes were the annual percentage changes of radius and tibia epi- and diaphysis bone geometry (total and cortical crosssectional area (CSA) and cortical thickness), and of volumetric bone mineral density (bone mineral content (BMC) and total, trabecular and cortical volumetric bone mineral density (vBMD)). We performed linear regression of the annual percentage changes adjusted for sex, LT4 dose at randomization and muscle crosssectional area. The 98 included participants had a mean age of 73.9 (+/- SD 5.4) years, 45.9% were women, and 12% had osteoporosis. They were randomized to placebo (n = 48) or LT4 (n = 50). Annual changes in BMC and vBMD were similar between placebo and LT4-treated groups, without significant difference in bone geometry or volumetric bone mineral density changes, neither at the diaphysis, nor at the epiphysis. For example, in the placebo group, epiphyseal BMC (radius) decreased by a mean 0.2% per year, with a similar decrease of 0.5% per year in the LT4 group (between-group difference in %Delta BMC 0.3, 95% CI -0.70 to 1.21, p = 0.91). Compared to placebo, LT4 therapy for an average 14 months had no significant effect on bone mass, bone geometry and volumetric density in older adults with subclinical hypothyroidism. Trial registration: The trial was registered on ClinicalTrials.gov numbers NCT01660126 (TRUST Thyroid trial) and NCT02491008 (Skeletal outcomes).

Details

Language :
English
ISSN :
18732763 and 87563282
Database :
OpenAIRE
Journal :
B&#252;chi, A E, Feller, M, Netzer, S, Blum, M R, Gonzalez Rodriguez, E, Collet, T-H, Del Giovane, C, van Heemst, D, Quinn, T, Kearney, P M, Westendorp, R G J, Gussekloo, J, Mooijaart, S P, Hans, D, Bauer, D C, Rodondi, N &amp; Aeberli, D 2022, &#39; Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy : A nested study within a randomized placebo controlled trial &#39;, Bone, vol. 161, 116404 . https://doi.org/10.1016/j.bone.2022.116404, Bone (2022) P. 116404, Bone, 161. ELSEVIER SCIENCE INC, B&#252;chi, Annina Elisabeth; Feller, Martin; Netzer, Seraina; Blum, Manuel R; Rodriguez, Elena Gonzalez; Collet, Tinh-Hai; Del Giovane, Cinzia; van Heemst, Diana; Quinn, Terry; Kearney, Patricia M; Westendorp, Rudi G J; Gussekloo, Jacobijn; Mooijaart, Simon; Hans, Didier; Bauer, Douglas C; Rodondi, Nicolas; Aeberli, Daniel (2022). Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy: A nested study within a randomized placebo controlled trial. Bone, 161, p. 116404. Elsevier 10.1016/j.bone.2022.116404 <http://dx.doi.org/10.1016/j.bone.2022.116404>
Accession number :
edsair.doi.dedup.....594e321bb1bdf1f2ced15e37e168034d
Full Text :
https://doi.org/10.1016/j.bone.2022.116404