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FOLFIRI in patients with locally advanced or metastatic pancreatic or biliary tract carcinoma

Authors :
Lucia Raimondo
Sabino De Placido
Chiara Carlomagno
Chiara Alessandra Cella
Roberto Moretto
Alfonso De Stefano
Elide Matano
Moretto, Roberto
Raimondo, Lucia
DE STEFANO, Alfonso
Cella, CHIARA ALESSANDRA
Matano, E
DE PLACIDO, Sabino
Carlomagno, Chiara
Source :
Anti-Cancer Drugs. 24:980-985
Publication Year :
2013
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2013.

Abstract

Pancreatic and biliary tract carcinomas are very chemoresistant. After a first-line treatment with a gemcitabine-based regimen, no second-line scheme is consolidated in clinical practice. The aim of this study was to evaluate the toxicity and the activity of the FOLFIRI regimen as first-line or second-line chemotherapy in patients with pancreatic or biliary tract tumors. Fifty-four patients (30 with pancreatic tumor, nine with gallbladder tumor, and 15 with biliary tract tumor) were treated with FOLFIRI (irinotecan 180 mg/m², day 1; leucovorin 100 mg/m² intravenously, days 1 and 2; 5-fluorouracil 400 mg/m² intravenous bolus, days 1 and 2; and 600 mg/m² in 22 h intravenously, continuous infusion days 1 and 2; every 14 days). Toxicity was recorded at each cycle according to the NCI-CTC V3.0 criteria, the response rate was verified each four cycles according to the RECIST criteria, and the progression-free survival rates as well as the overall survival rates were calculated according to the Kaplan-Meier method. Overall, the toxicity was mild. Grade 3-4 neutropenia occurred in 42.6% of patients. Grade 3-4 gastrointestinal toxicity was rare. FOLFIRI as a first-line treatment produced a response rate of 25%. In the second-line group, 9/21 patients (42.9%) obtained a stable disease as best response. In the entire population, the median progression-free survival rates were 3.1 months [95% confidence interval (CI), 1.9-4.4] and 3.5 months (95% CI, 2.6-4.4), respectively, in the first-line and the second-line cohort of patients. The median overall survival rates were 14.5 months (95% CI, 7.0-22.1) and 6.2 months (95% CI, 5.4-7.0), respectively, in the first-line and the second-line cohort of patients. FOLFIRI is feasible and well tolerated in patients with pancreatic or biliary tract tumors; it has a good activity in first line and mostly in patients with pancreatic cancer.

Details

ISSN :
09594973
Volume :
24
Database :
OpenAIRE
Journal :
Anti-Cancer Drugs
Accession number :
edsair.doi.dedup.....5996489a5275ffbbce8fd066119a12b9
Full Text :
https://doi.org/10.1097/cad.0b013e328364e66b