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Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice
- Source :
- Journal of Pharmacological Sciences, Vol 147, Iss 1, Pp 58-61 (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Nicotine administration enhances object recognition memory. However, target brain regions and cellular mechanisms underlying the nicotine effects remain unclear. In mice, the novel object recognition test revealed that systemic nicotine administration before training enhanced object recognition memory. Moreover, this effect was inhibited by infusion of retigabine, a selective voltage-dependent potassium 7 (Kv7) channel opener, into the medial prefrontal cortex (mPFC) before nicotine administration. Additionally, infusion of XE-991, a selective Kv7 channel blocker, into the mPFC before training enhanced object recognition memory. Therefore, Kv7 channels in the mPFC may be at least partly involved in nicotine-induced enhancement of object recognition memory.
- Subjects :
- Male
0301 basic medicine
Nicotine
Kv7 channels
Potassium
Prefrontal Cortex
chemistry.chemical_element
RM1-950
Phenylenediamines
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Memory
medicine
Animals
Channel blocker
Novel object recognition
Prefrontal cortex
Anthracenes
Pharmacology
Voltage-dependent potassium 7 channels
Retigabine
Cognitive neuroscience of visual object recognition
Recognition, Psychology
Medial prefrontal cortex
Stimulation, Chemical
Mice, Inbred C57BL
030104 developmental biology
chemistry
Potassium Channels, Voltage-Gated
Molecular Medicine
Carbamates
Therapeutics. Pharmacology
Neuroscience
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 13478613
- Volume :
- 147
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacological Sciences
- Accession number :
- edsair.doi.dedup.....5996d1fcd98a8794fcbbfd2fa548fc5f