Back to Search
Start Over
Chromosomal structural variations during progression of a prostate epithelial cell line to a malignant metastatic state inactivate the NF2, NIPSNAP1, UGT2B17, and LPIN2 genes
Chromosomal structural variations during progression of a prostate epithelial cell line to a malignant metastatic state inactivate the NF2, NIPSNAP1, UGT2B17, and LPIN2 genes
- Source :
- Cancer Biology & Therapy
- Publication Year :
- 2013
- Publisher :
- Informa UK Limited, 2013.
-
Abstract
- Prostate cancer is the second highest cause of male cancer deaths in the United States. A significant number of tumors advance to a highly invasive and metastatic stage, which is typically resistant to traditional cancer therapeutics. In order to identify chromosomal structural variants that may contribute to prostate cancer progression we sequenced the genomes of a HPV-18 immortalized nonmalignant human prostate epithelial cell line, RWPE1, and compared it to its malignant, metastatic derivative, WPE1-NB26. There were a total of 34 large (>1 Mbp) and 38 small copy number variants (
- Subjects :
- Male
Cancer Research
Carcinogenesis
Biology
medicine.disease_cause
high throughput sequencing
complex rearrangements
Metastasis
Minor Histocompatibility Antigens
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Prostate
Cell Line, Tumor
HYDRA
medicine
metastasis
Humans
Genes, Tumor Suppressor
Neoplasm Invasiveness
Copy-number variation
Glucuronosyltransferase
Neoplasm Metastasis
030304 developmental biology
Pharmacology
Genetics
0303 health sciences
Oncogene
Nuclear Proteins
Prostatic Neoplasms
Epithelial Cells
Chromoplexy
prostate cancer
medicine.disease
AbCNV
3. Good health
medicine.anatomical_structure
Oncology
NF2
030220 oncology & carcinogenesis
Dihydrotestosterone
NIPSNAP1
Genomic Structural Variation
Cancer research
Molecular Medicine
Research Paper
medicine.drug
Subjects
Details
- ISSN :
- 15558576 and 15384047
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Cancer Biology & Therapy
- Accession number :
- edsair.doi.dedup.....59a4de9a7838c25fad7f590b414d9058
- Full Text :
- https://doi.org/10.4161/cbt.25329