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Chromosomal structural variations during progression of a prostate epithelial cell line to a malignant metastatic state inactivate the NF2, NIPSNAP1, UGT2B17, and LPIN2 genes

Chromosomal structural variations during progression of a prostate epithelial cell line to a malignant metastatic state inactivate the NF2, NIPSNAP1, UGT2B17, and LPIN2 genes

Authors :
Anindya Dutta
Ira M. Hall
Yoshiyuki Shibata
Ankit Malhotra
Source :
Cancer Biology & Therapy
Publication Year :
2013
Publisher :
Informa UK Limited, 2013.

Abstract

Prostate cancer is the second highest cause of male cancer deaths in the United States. A significant number of tumors advance to a highly invasive and metastatic stage, which is typically resistant to traditional cancer therapeutics. In order to identify chromosomal structural variants that may contribute to prostate cancer progression we sequenced the genomes of a HPV-18 immortalized nonmalignant human prostate epithelial cell line, RWPE1, and compared it to its malignant, metastatic derivative, WPE1-NB26. There were a total of 34 large (>1 Mbp) and 38 small copy number variants (

Details

ISSN :
15558576 and 15384047
Volume :
14
Database :
OpenAIRE
Journal :
Cancer Biology & Therapy
Accession number :
edsair.doi.dedup.....59a4de9a7838c25fad7f590b414d9058
Full Text :
https://doi.org/10.4161/cbt.25329