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Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic cochrane hepato-biliary group review with meta-analyses of randomized clinical trials
- Source :
- The American journal of gastroenterology. 100(11)
- Publication Year :
- 2005
-
Abstract
- Our objectives were to assess the beneficial and harmful effects of milk thistle (MT) or MT constituents versus placebo or no intervention in patients with alcoholic liver disease and/or hepatitis B and/or C liver diseases.Randomized clinical trials studying patients with alcoholic and/or hepatitis B or C liver diseases were included (December 2003). The randomized clinical trials were evaluated by components of methodological quality.Thirteen randomized clinical trials assessed MT in 915 patients with alcoholic and/or hepatitis B or C liver diseases. The methodological quality was low: only 23% of the trials reported adequate allocation concealment and only 46% were considered double blind. MT versus placebo or no intervention for a median duration of 6 months had no significant effects on all-cause mortality (relative risk (RR) 0.78, 95% confidence interval (CI) 0.53-1.15), complications of liver disease, or liver histology. Liver-related mortality was significantly reduced by MT in all trials (RR 0.50, 95% CI 0.29-0.88), but not in high-quality trials (RR 0.57, 95% CI 0.28-1.19). MT was not associated with a significantly increased risk of adverse events.Based on high-quality trials, MT does not seem to significantly influence the course of patients with alcoholic and/or hepatitis B or C liver diseases. MT could potentially affect liver injury. Adequately conducted randomized clinical trials on MT versus placebo may be needed.
- Subjects :
- medicine.medical_specialty
Time Factors
education
MEDLINE
Gastroenterology
law.invention
Placebos
Randomized controlled trial
Double-Blind Method
law
Internal medicine
Cause of Death
Medicine
Humans
Milk Thistle
Cause of death
Randomized Controlled Trials as Topic
Hepatitis
Hepatology
business.industry
Hepatitis, Alcoholic
Hepatitis B
medicine.disease
Hepatitis C
Clinical trial
Treatment Outcome
Biliary tract
Research Design
Immunology
Plant Preparations
business
Phytotherapy
Subjects
Details
- ISSN :
- 00029270
- Volume :
- 100
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- The American journal of gastroenterology
- Accession number :
- edsair.doi.dedup.....59c692eb4db84a91f8b42432bd2dd29b