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Calprotectin and neutrophil gelatinase-associated lipocalin in the differentiation of pre-renal and intrinsic acute kidney injury

Authors :
Frank Heller
Timm H. Westhoff
Robert Arndt
F. Seibert
Duska Dragun
Nikolaos Pagonas
Walter Zidek
Pontus B. Persson
Kai M. Schmidt-Ott
Source :
Acta Physiologica. 207:700-708
Publication Year :
2013
Publisher :
Wiley, 2013.

Abstract

BACKGROUND: Urinary calprotectin has recently been identified as a promising biomarker for the differentiation of prerenal and intrinsic acute kidney injury (AKI). The present study compares the diagnostic performance of calprotectin and neutrophil gelatinase-associated lipocalin (NGAL) in this differential diagnosis. METHODS: Urinary calprotectin and NGAL concentrations were assessed in a study population of 87 subjects including 38 cases of intrinsic AKI, 24 cases of prerenal AKI, and 25 healthy controls. Urinary tract obstruction, renal transplantation and metastatic cancer were defined as exclusion criteria. RESULTS: Mean calprotectin concentrations were significantly lower in prerenal (190.2+/-205.7 ng/ml) than in intrinsic AKI (6250.1+/-7167.2 ng/ml, p

Details

ISSN :
17481708
Volume :
207
Database :
OpenAIRE
Journal :
Acta Physiologica
Accession number :
edsair.doi.dedup.....59f58ff8b020950091916bcfd705f494
Full Text :
https://doi.org/10.1111/apha.12064