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Calprotectin and neutrophil gelatinase-associated lipocalin in the differentiation of pre-renal and intrinsic acute kidney injury
- Source :
- Acta Physiologica. 207:700-708
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- BACKGROUND: Urinary calprotectin has recently been identified as a promising biomarker for the differentiation of prerenal and intrinsic acute kidney injury (AKI). The present study compares the diagnostic performance of calprotectin and neutrophil gelatinase-associated lipocalin (NGAL) in this differential diagnosis. METHODS: Urinary calprotectin and NGAL concentrations were assessed in a study population of 87 subjects including 38 cases of intrinsic AKI, 24 cases of prerenal AKI, and 25 healthy controls. Urinary tract obstruction, renal transplantation and metastatic cancer were defined as exclusion criteria. RESULTS: Mean calprotectin concentrations were significantly lower in prerenal (190.2+/-205.7 ng/ml) than in intrinsic AKI (6250.1+/-7167.2 ng/ml, p
- Subjects :
- Male
medicine.medical_specialty
Pathology
Physiology
Biopsy
Urinary system
Population
Kidney
urologic and male genital diseases
Sensitivity and Specificity
Gastroenterology
Diagnosis, Differential
fluids and secretions
Lipocalin-2
Proto-Oncogene Proteins
Internal medicine
medicine
Humans
education
Aged
Aged, 80 and over
education.field_of_study
business.industry
Acute kidney injury
Kidney metabolism
Acute Kidney Injury
Middle Aged
medicine.disease
Lipocalins
Pyuria
Transplantation
Cross-Sectional Studies
medicine.anatomical_structure
ROC Curve
Area Under Curve
Case-Control Studies
Female
medicine.symptom
Calprotectin
business
Leukocyte L1 Antigen Complex
Biomarkers
Acute-Phase Proteins
Subjects
Details
- ISSN :
- 17481708
- Volume :
- 207
- Database :
- OpenAIRE
- Journal :
- Acta Physiologica
- Accession number :
- edsair.doi.dedup.....59f58ff8b020950091916bcfd705f494
- Full Text :
- https://doi.org/10.1111/apha.12064