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State-of-Art of Cellular Therapy for Acute Leukemia
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 4590, p 4590 (2021), International Journal of Molecular Sciences
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- With recent clinical breakthroughs, immunotherapy has become the fourth pillar of cancer treatment. Particularly, immune cell-based therapies have been envisioned as a promising treatment option with curative potential for leukemia patients. Hence, an increasing number of preclinical and clinical studies focus on various approaches of immune cell-based therapy for treatment of acute leukemia (AL). However, the use of different immune cell lineages and subsets against different types of leukemia and patient disease statuses challenge the interpretation of the clinical applicability and outcome of immune cell-based therapies. This review aims to provide an overview on recent approaches using various immune cell-based therapies against acute B-, T-, and myeloid leukemias. Further, the apparent limitations observed and potential approaches to overcome these limitations are discussed.
- Subjects :
- 0301 basic medicine
Myeloid
Leukemia, T-Cell
QH301-705.5
medicine.medical_treatment
T-Lymphocytes
CAR-T cell
Cell
Cell- and Tissue-Based Therapy
Disease
Review
Bioinformatics
Immunotherapy, Adoptive
Catalysis
Inorganic Chemistry
Cell therapy
03 medical and health sciences
0302 clinical medicine
Immune system
medicine
Humans
NK cell
acute leukemia
Physical and Theoretical Chemistry
Biology (General)
Molecular Biology
QD1-999
Spectroscopy
Acute leukemia
Receptors, Chimeric Antigen
business.industry
Organic Chemistry
General Medicine
Immunotherapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
DNT cell
Computer Science Applications
Killer Cells, Natural
Leukemia
Leukemia, Myeloid, Acute
Chemistry
030104 developmental biology
medicine.anatomical_structure
adoptive cellular therapy
030220 oncology & carcinogenesis
Acute Disease
business
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 22
- Issue :
- 4590
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....59faec6b36ff3ae32b582fdf8a210209