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Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase
- Source :
- Biochemical and Biophysical Research Communications. 148:617-622
- Publication Year :
- 1987
- Publisher :
- Elsevier BV, 1987.
-
Abstract
- The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted α-helix-turn-α-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3′ untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.
- Subjects :
- Untranslated region
Poly ADP ribose polymerase
Molecular Sequence Data
Biophysics
Biochemistry
chemistry.chemical_compound
Sequence Homology, Nucleic Acid
Complementary DNA
Humans
Amino Acid Sequence
Molecular Biology
Polymerase
Messenger RNA
Base Sequence
biology
Nucleic acid sequence
DNA
Cell Biology
DNA-binding domain
Fibroblasts
Molecular biology
chemistry
biology.protein
Poly(ADP-ribose) Polymerases
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 148
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....5a08e4c3f2e26b6210a16a56bbdfe61f