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Efficacy and safety of ceftolozane/tazobactam as therapeutic option for complicated skin and soft tissue infections by MDR/XDR Pseudomonas aeruginosa in patients with impaired renal function: a case series from a single-center experience
- Publication Year :
- 2020
-
Abstract
- Introduction: Pseudomonas aeruginosa (PA) is a known cause of skin and soft tissue infections (SSTIs). Therapeutic options against multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of PA are limited, especially in patients with impaired renal function. Ceftolozane/tazobactam (C/T) is a novel beta-lactam/beta-lactamase inhibitor with powerful anti-PA activity. Thanks to its characteristics, it appears to be the best available anti-pseudomonal drug in many clinical scenarios. A case series of four adult patients followed between January 2018 and May 2019 is reported. All subjects presented complicated SSTIs by MDR- or XDR-PA and were affected by chronic kidney disease. Results: C/T was used as a monotherapy in three cases and in combination regimen in the remaining case. In two cases, C/T was the first-line option, in the remaining ones was the salvage treatment. All patients were successfully treated without worsening of renal function and without any other adverse events. Conclusions: C/T may represent a useful option against MDR- and XDR-PA strains responsible of complicated SSTIs in patients affected by impaired renal function.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Tazobactam
Antibiotic resistance
030106 microbiology
Renal function
Single Center
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Pseudomonas Infections
030212 general & internal medicine
Adverse effect
Aged
Aged, 80 and over
business.industry
Pseudomonas aeruginosa
Soft Tissue Infections
Skin and soft tissue infections
General Medicine
Skin Diseases, Bacterial
Middle Aged
Kidney disease
medicine.disease
Ceftolozane/tazobactam
Anti-Bacterial Agents
Cephalosporins
Regimen
Infectious Diseases
Treatment Outcome
Ceftolozane
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....5a10de450c747b04f3a8f07225cc2991