Back to Search
Start Over
Synergy of pancratistatin and tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria
- Source :
- Cancer Biology & Therapy. 7:376-384
- Publication Year :
- 2008
- Publisher :
- Informa UK Limited, 2008.
-
Abstract
- Pancratistatin (PST), a natural compound obtained from the Hawaiian spider lily, is known to be specific and selective in inducing apoptosis in multiple cancer cell lines while sparing non-cancerous cells and cell lines. Here we report the ability of PST to induce apoptosis specifically in human breast cancer cell lines MCF-7 and Hs-578-T compared to their non cancerous counterparts. In cancer cells PST caused increased levels of reactive oxygen species (ROS), decreased ATP and mitochondrial membrane permeabilization indicating the activation of the mitochondrial pathway of apoptosis. In combination with the anti-estrogen Tamoxifen, PST had a synergic effect. Both compounds caused increased production of ROS when applied to isolated mitochondria from these cancer cell lines supporting the observation that Tamoxifen might work through mechanisms distinct from the canonical estrogen receptor antagonism.
- Subjects :
- Cancer Research
medicine.medical_specialty
Antineoplastic Agents, Hormonal
Estrogen receptor
Apoptosis
Breast Neoplasms
Pancratistatin
Mitochondrion
Biology
chemistry.chemical_compound
Internal medicine
medicine
Humans
Cell Nucleus
Pharmacology
chemistry.chemical_classification
Reactive oxygen species
food and beverages
Isoquinolines
Mitochondria
Kinetics
Tamoxifen
Endocrinology
Oncology
chemistry
Cell culture
Cancer cell
Amaryllidaceae Alkaloids
Cancer research
Molecular Medicine
Female
Cell Division
medicine.drug
Subjects
Details
- ISSN :
- 15558576 and 15384047
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Cancer Biology & Therapy
- Accession number :
- edsair.doi.dedup.....5a334719617d851356a013e9853becee
- Full Text :
- https://doi.org/10.4161/cbt.7.3.5364