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DDX3X Sits at the Crossroads of Liquid–Liquid and Prionoid Phase Transitions Arbitrating Life and Death Cell Fate Decisions in Stressed Cells
- Source :
- DNA Cell Biol
- Publication Year :
- 2020
- Publisher :
- Mary Ann Liebert Inc, 2020.
-
Abstract
- The crosstalk between cellular stress responses and innate immune signaling pathways remains poorly understood. Cells can respond to stressors by assembling stress granules that store 40S ribosomes, translation initiation factors, and mRNAs, and allow the cell to survive. Some stressors can activate the NLRP3 inflammasome, which leads to pyroptotic cell death. Stress granules and the NLRP3 inflammasome provide distinct cell fate choices to the cell. These complexes also involve distinct types of phase transitions-liquid-liquid phase separation for stress granules and prionoid phase transition for the NLRP3 inflammasome. We recently reported that DDX3X modulates this crosstalk by acting as a common essential factor for NLRP3 inflammasome activation and stress granule assembly. Here, we discuss the role of DDX3X in modulating the liquid-liquid phase separation and prionoid phase transition required for making cell fate decisions under stress conditions.
- Subjects :
- 0301 basic medicine
Cell
Cell fate determination
Biology
DNACB Bit
DEAD-box RNA Helicases
03 medical and health sciences
0302 clinical medicine
Stress granule
Genetics
medicine
Animals
Humans
Stress granule assembly
Molecular Biology
Innate immune system
Cell Death
integumentary system
Inflammasome
Receptor Cross-Talk
Cell Biology
General Medicine
Cell biology
Crosstalk (biology)
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Signal transduction
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 15577430 and 10445498
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- DNA and Cell Biology
- Accession number :
- edsair.doi.dedup.....5a3e9ea72ea76c5e764ee33f5bdfbae4