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Postnatal symptomatic Zika virus infections in children and adolescents: A systematic review
- Source :
- PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008612 (2020), PLoS Neglected Tropical Diseases
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- Background Recent Zika virus (ZIKV) outbreaks in the Pacific and the Americas have highlighted clinically significant congenital neurological abnormalities resulting from ZIKV infection in pregnancy. However, little is known about ZIKV infections in children and adolescents, a group that is potentially vulnerable to ZIKV neurovirulence. Methods We conducted a systematic review on the clinical presentation and complications of children and adolescents aged 0 to 18 years with a robust diagnosis of ZIKV infection. We searched PubMed, Web of Science, LILACs, and EMBASE until 13 February 2020 and screened reference lists of eligible articles. We assessed the studies’ risk of bias using pre-specified criteria. Findings Our review collated the evidence from 2543 pediatric ZIKV cases representing 17 countries and territories, identified in 1 cohort study, 9 case series and 22 case reports. The most commonly observed signs and symptoms of ZIKV infection in children and adolescents were mild and included fever, rash, conjunctivitis and arthralgia. The frequency of neurological complications was reported only in the largest case series (identified in 1.0% of cases) and in an additional 14 children identified from hospital-based surveillance studies and case reports. ZIKV-related mortality was primarily accompanied by co-morbidity and was reported in one case series (<br />Author summary Although the number of Zika virus (ZIKV) cases has declined following the 2015–2016 outbreak in the Americas, ZIKV remains a public health concern due to the potentially severe consequences of in utero exposure to the virus. While there is an increasing understanding of the effects of prenatal congenital ZIKV infection, less is known regarding the potential consequences of postnatal non-congenital ZIKV infection in children and adolescents. As this age group may also be vulnerable to the adverse effects of ZIKV on the nervous system, a better understanding of ZIKV infection in this population is needed. This knowledge may help to inform the case definition for ZIKV disease in children and elucidate whether children and adolescents should be included in strategies and measures for prevention of ZIKV infection, which are currently aimed primarily at pregnant women. After a review of the existing literature, the authors found that ZIKV infection in children and adolescents appears to be similar to adults and primarily mild, with little evidence of severe neurological consequences. Further research using prospective methods and neurodevelopmental assessments is warranted.
- Subjects :
- 0301 basic medicine
RNA viruses
Male
Pediatrics
RC955-962
Infektionsmedicin
Comorbidity
Dengue virus
medicine.disease_cause
Pathology and Laboratory Medicine
Adolescents
Zika virus
Families
0302 clinical medicine
Medical Conditions
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Medicine
Case Series
Prospective cohort study
Child
Children
Chikungunya Virus
biology
Zika Virus Infection
Rash
3. Good health
Infectious Diseases
Medical Microbiology
Research Design
Viral Pathogens
Child, Preschool
Viruses
Female
medicine.symptom
Pathogens
Public aspects of medicine
RA1-1270
Pediatric Infections
Cohort study
Research Article
Neglected Tropical Diseases
medicine.medical_specialty
Infectious Medicine
Adolescent
Clinical Research Design
Alphaviruses
030231 tropical medicine
MEDLINE
Research and Analysis Methods
Microbiology
Togaviruses
03 medical and health sciences
Humans
Microbial Pathogens
Pregnancy
Biology and life sciences
Flaviviruses
business.industry
Public Health, Environmental and Occupational Health
Organisms
Infant, Newborn
Outbreak
Infant
Zika Virus
Dengue Virus
biology.organism_classification
medicine.disease
Tropical Diseases
Zika Fever
030104 developmental biology
Age Groups
People and Places
Population Groupings
Nervous System Diseases
business
Subjects
Details
- Language :
- English
- ISSN :
- 19352735 and 19352727
- Volume :
- 14
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS Neglected Tropical Diseases
- Accession number :
- edsair.doi.dedup.....5a3f243732ebb99b2436e755b00f9ce4