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Pd(0)-Catalyzed Diastereo- and Enantioselective Intermolecular Cycloaddition for Rapid Assembly of 2-Acyl-methylenecyclopentanes
- Source :
- Organic letters. 23(3)
- Publication Year :
- 2021
-
Abstract
- A highly regio-, diastereo-, and enantioselective trimethylenemethane (TMM) cycloaddition reaction for the rapid assembly of 2-acyl-methylenecyclopentane in an atom-economic fashion is described. This intermolecular protocol allows for facile and divergent access to an array of structurally attractive cyclic adducts. The choice of a robust chiral diamidophosphite ligand, developed by our group, proved to be crucial for the success of this transformation.
- Subjects :
- 010405 organic chemistry
Chemistry
Ligand
Organic Chemistry
Trimethylenemethane
Intermolecular force
Enantioselective synthesis
010402 general chemistry
01 natural sciences
Biochemistry
Combinatorial chemistry
Cycloaddition
0104 chemical sciences
Adduct
Catalysis
chemistry.chemical_compound
Physical and Theoretical Chemistry
Subjects
Details
- ISSN :
- 15237052
- Volume :
- 23
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....5a42e4f964e595d78d53bf939eb0e332