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Metabolic and morphological alterations of brown adipose tissue after sympathetic denervation in rats
- Source :
- Journal of the Autonomic Nervous System. 15:197-204
- Publication Year :
- 1986
- Publisher :
- Elsevier BV, 1986.
-
Abstract
- Effects of sympathetic denervation on biochemical and morphological changes of brown adipose tissue (BAT) were studied in rats after severing 5 intercostal nerve bundles that enter the unilateral interscapular BAT, the contralateral BAT being used as the control. Four weeks after denervation, there was no appreciable change in BAT weight or its DNA and protein contents, whereas the triglyceride content was increased significantly. However, the rate of fatty acid synthesis was decreased to about half the rate in controls. The denervated BAT was much paler than controls and contained lots of adipocytes filled with large lipid droplets, some of which were unilocular. The results are discussed with reference to changes in BAT seen after bilateral lesions of the ventromedial hypothalamus.
- Subjects :
- medicine.medical_specialty
Time Factors
animal structures
Physiology
Intercostal nerves
Biology
Sympathetic Denervation
Norepinephrine
chemistry.chemical_compound
Adipose Tissue, Brown
Internal medicine
Brown adipose tissue
medicine
Animals
Sympathectomy
Triglycerides
Fatty acid synthesis
Denervation
General Neuroscience
Fatty Acids
Rats, Inbred Strains
Organ Size
Metabolism
Rats
Triglyceride content
Endocrinology
medicine.anatomical_structure
chemistry
Ventromedial Hypothalamic Nucleus
Hypothalamus
Female
Neurology (clinical)
Subjects
Details
- ISSN :
- 01651838
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Journal of the Autonomic Nervous System
- Accession number :
- edsair.doi.dedup.....5a49a03151954bf992c64efcd96a7f13