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Toxic effects of chlorpromazine onCarassius auratusand its oxidative stress
- Source :
- Journal of Environmental Science and Health, Part B. 43:638-643
- Publication Year :
- 2008
- Publisher :
- Informa UK Limited, 2008.
-
Abstract
- Under laboratory conditions, ecotoxicological effects of chlorpromazine (CPZ) on freshwater goldfish (Carassius auratus) were examined using the toxic culture experiment. The results showed that the median lethal concentration (LC(50)) of CPZ toxic to Carassius auratus in 24, 48 and 96 h was 1.11, 0.43 and 0.32 mg/L, respectively. Thus, CPZ is an extreme toxicant to goldfish. Furthermore, there were significantly positive correlations between the ecotoxicological effects of CPZ and its concentrations, and the toxicity became higher as the exposure time increased. The activity of superoxide dismutase (SOD) and catalase (CAT) in goldfish livers was significantly influenced by CPZ. At the same exposure time, the activity of SOD reduced first, and increased then, whereas the activity of CAT enhanced first and decreased then. At the same exposure levels of CPZ, the activity of SOD and CAT changed similarly, decreased first, then increased and decreased at last. Within the range of exposure concentrations, the changes in the activity of CAT can more easily reflect the oxidation stress in Carassius auratus by CPZ than those of SOD.
- Subjects :
- medicine.medical_specialty
Time Factors
Chlorpromazine
Median lethal dose
Lethal Dose 50
Superoxide dismutase
Toxicology
Random Allocation
chemistry.chemical_compound
Goldfish
Internal medicine
medicine
Animals
Chronic toxicity
Dose-Response Relationship, Drug
biology
Superoxide Dismutase
General Medicine
Environmental exposure
Catalase
Pollution
Oxidative Stress
Dose–response relationship
Endocrinology
chemistry
Toxicity
biology.protein
sense organs
Water Pollutants, Chemical
Food Science
Toxicant
Subjects
Details
- ISSN :
- 15324109 and 03601234
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Journal of Environmental Science and Health, Part B
- Accession number :
- edsair.doi.dedup.....5a5f5448c74c6a500daac2dce3119989