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Correlation between the GP78 Gene Polymorphism and Coronary Atherosclerotic Heart Disease
- Source :
- Hellenic Journal of Cardiology, Vol 59, Iss 1, Pp 8-13 (2018)
- Publication Year :
- 2017
-
Abstract
- Objective: To study the correlation between the GP78 gene polymorphism and blood fat, blood glucose, blood pressure and coronary atherosclerotic heart disease. Methods: A total of 72 patients with coronary atherosclerotic heart disease were selected as the observation group, and 68 healthy participants were selected as the control group. The gp78 gene polymorphism of both groups was studied via polymerase chain reaction-restriction fragment length polymorphism (RFLP). At the same time, the multiple expression quantities of the GP78 gene in the tissues of both groups were tested via fluorogenic quantitative PCR, enzyme-linked immunosorbent assay (ELISA) and Western-blotting assay. Furthermore, the blood fat, blood glucose and blood pressure of subjects in both groups were tested. Results: The percentages of the gp78 gene polymorphisms of Arg/Arg, Arg/Gly and Gly/Gly at the 145 locus of the study subjects in the observation group were 12.3%, 43.2% and 44.5%, respectively, while those in the control group were 74.3%, 11.2% and 14.5%, respectively, and there were significant differences between both groups. Based on the test results of the blood fat, blood glucose and blood pressure of the objects in the observation group and control group, significant differences were found between the two groups (P
- Subjects :
- 0301 basic medicine
Adult
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Heart disease
Genotype
Blotting, Western
Blood lipids
Locus (genetics)
Enzyme-Linked Immunosorbent Assay
Coronary Artery Disease
030204 cardiovascular system & hematology
Polymerase Chain Reaction
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Gene
Retrospective Studies
Medicine(all)
Polymorphism, Genetic
business.industry
DNA
Middle Aged
medicine.disease
Atherosclerosis
Receptors, Autocrine Motility Factor
030104 developmental biology
Real-time polymerase chain reaction
Endocrinology
Blood pressure
lcsh:RC666-701
Cardiology
Female
Gene polymorphism
Restriction fragment length polymorphism
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 22415955
- Volume :
- 59
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese
- Accession number :
- edsair.doi.dedup.....5a65b509578030396da77fd12f977336