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Characterisation of age and polarity at onset in bipolar disorder
- Source :
- The British journal of psychiatry 219(6), 659-669 (2021). doi:10.1192/bjp.2021.102, British Journal of Psychiatry, British Journal of Psychiatry, 2021, 219 (6), pp.659-669. ⟨10.1192/bjp.2021.102⟩, British Journal of Psychiatry, Royal College of Psychiatrists, 2021, 219 (6), pp.659-669. ⟨10.1192/bjp.2021.102⟩, British Journal of Psychiatry, 219(6), 659-669. Royal College of Psychiatrists, The British Journal of Psychiatry, Kalman, J L, Olde Loohuis, L M, Vreeker, A, McQuillin, A, Stahl, E A, Ruderfer, D, Grigoroiu-Serbanescu, M, Panagiotaropoulou, G, Ripke, S, Bigdeli, T B, Stein, F, Meller, T, Meinert, S, Pelin, H, Streit, F, Papiol, S, Adams, M J, Adolfsson, R, Adorjan, K, Agartz, I, Aminoff, S R, Anderson-Schmidt, H, Andreassen, O A, Ardau, R, Aubry, J M, Balaban, C, Bass, N, Baune, B T, Bellivier, F, Benabarre, A, Bengesser, S, Berrettini, W H, Boks, M P, Bromet, E J, Brosch, K, Budde, M, Byerley, W, Cervantes, P, Chillotti, C, Cichon, S, Clark, S R, Comes, A L, Corvin, A, Coryell, W, Craddock, N, Craig, D W, Croarkin, P E, Cruceanu, C, Czerski, P M, Dalkner, N, Dannlowski, U, Degenhardt, F, Del Zompo, M, DePaulo, J R, Djurovic, S, Edenberg, H J, Al Eissa, M, Elvsåshagen, T, Etain, B, Fanous, A H, Fellendorf, F, Fiorentino, A, Forstner, A J, Frye, M A, Fullerton, J M, Gade, K, Garnham, J, Gershon, E, Gill, M, Goes, F S, Gordon-Smith, K, Grof, P, Guzman-Parra, J, Hahn, T, Hasler, R, Heilbronner, M, Heilbronner, U, Jamain, S, Jimenez, E, Jones, I, Jones, L, Jonsson, L, Kahn, R S, Kelsoe, J R, Kennedy, J L, Kircher, T, Kirov, G, Kittel-Schneider, S, Klöhn-Saghatolislam, F, Knowles, J A, Kranz, T M, Lagerberg, T V, Landen, M, Lawson, W B, Leboyer, M, Li, Q S, Maj, M, Malaspina, D, Manchia, M, Mayoral, F, McElroy, S L, McInnis, M G, McIntosh, A M, Medeiros, H, Melle, I, Milanova, V, Mitchell, P B, Monteleone, P, Monteleone, A M, Nöthen, M M, Novak, T, Nurnberger, J I, O'Brien, N, O'Connell, K S, O'Donovan, C, O'Donovan, M C, Opel, N, Ortiz, A, Owen, M J, Pålsson, E, Pato, C, Pato, M T, Pawlak, J, Pfarr, J K, Pisanu, C, Potash, J B, Rapaport, M H, Reich-Erkelenz, D, Reif, A, Reininghaus, E, Repple, J, Richard-Lepouriel, H, Rietschel, M, Ringwald, K, Roberts, G, Rouleau, G, Schaupp, S, Scheftner, W A, Schmitt, S, Schofield, P R, Schubert, K O, Schulte, E C, Schweizer, B, Senner, F, Severino, G, Sharp, S, Slaney, C, Smeland, O B, Sobell, J L, Squassina, A, Stopkova, P, Strauss, J, Tortorella, A, Turecki, G, Twarowska-Hauser, J, Veldic, M, Vieta, E, Vincent, J B, Xu, W, Zai, C C, Zandi, P P, Di Florio, A, Smoller, J W, Biernacka, J M, McMahon, F J, Alda, M, Müller-Myhsok, B, Koutsouleris, N, Falkai, P, Freimer, N B, Andlauer, T F M & Schulze, T G & Ophoff, R A 2021, ' Characterisation of age and polarity at onset in bipolar disorder ', British Journal of Psychiatry . https://doi.org/10.1192/bjp.2021.102, Print: 0007-1250 Online:1472-1465, The British Journal of Psychiatry, Vol. 219, No. 6
- Publication Year :
- 2021
- Publisher :
- Cambridge University Press, 2021.
-
Abstract
- BackgroundStudying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.AimsTo examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.MethodGenome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.ResultsEarlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.ConclusionsAAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
- Subjects :
- Paper
Multifactorial Inheritance
medicine.medical_specialty
Autism Spectrum Disorder
Bipolar disorder
MESH: Age of Onset
[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Medizin
GWAS
age at onset
polarity at onset
polygenic score
MESH: Depressive Disorder, Major
BF
Genome-wide association study
Disease
Psykiatri
SDG 3 - Good Health and Well-being
ddc:150
Polarity at onset
Internal medicine
MESH: Bipolar Disorder
Polygenic score
medicine
Humans
Academic Psychiatry
Age of Onset
Genetic association
Psychiatry
MESH: Autism Spectrum Disorder
Depressive Disorder, Major
MESH: Humans
business.industry
Age at onset
Heritability
medicine.disease
Genetic architecture
ddc
Psychiatry and Mental health
Schizophrenia
Autism spectrum disorder
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
MESH: Genome-Wide Association Study
RC0321
MESH: Multifactorial Inheritance
business
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 00071250
- Database :
- OpenAIRE
- Journal :
- The British journal of psychiatry 219(6), 659-669 (2021). doi:10.1192/bjp.2021.102, British Journal of Psychiatry, British Journal of Psychiatry, 2021, 219 (6), pp.659-669. ⟨10.1192/bjp.2021.102⟩, British Journal of Psychiatry, Royal College of Psychiatrists, 2021, 219 (6), pp.659-669. ⟨10.1192/bjp.2021.102⟩, British Journal of Psychiatry, 219(6), 659-669. Royal College of Psychiatrists, The British Journal of Psychiatry, Kalman, J L, Olde Loohuis, L M, Vreeker, A, McQuillin, A, Stahl, E A, Ruderfer, D, Grigoroiu-Serbanescu, M, Panagiotaropoulou, G, Ripke, S, Bigdeli, T B, Stein, F, Meller, T, Meinert, S, Pelin, H, Streit, F, Papiol, S, Adams, M J, Adolfsson, R, Adorjan, K, Agartz, I, Aminoff, S R, Anderson-Schmidt, H, Andreassen, O A, Ardau, R, Aubry, J M, Balaban, C, Bass, N, Baune, B T, Bellivier, F, Benabarre, A, Bengesser, S, Berrettini, W H, Boks, M P, Bromet, E J, Brosch, K, Budde, M, Byerley, W, Cervantes, P, Chillotti, C, Cichon, S, Clark, S R, Comes, A L, Corvin, A, Coryell, W, Craddock, N, Craig, D W, Croarkin, P E, Cruceanu, C, Czerski, P M, Dalkner, N, Dannlowski, U, Degenhardt, F, Del Zompo, M, DePaulo, J R, Djurovic, S, Edenberg, H J, Al Eissa, M, Elvsåshagen, T, Etain, B, Fanous, A H, Fellendorf, F, Fiorentino, A, Forstner, A J, Frye, M A, Fullerton, J M, Gade, K, Garnham, J, Gershon, E, Gill, M, Goes, F S, Gordon-Smith, K, Grof, P, Guzman-Parra, J, Hahn, T, Hasler, R, Heilbronner, M, Heilbronner, U, Jamain, S, Jimenez, E, Jones, I, Jones, L, Jonsson, L, Kahn, R S, Kelsoe, J R, Kennedy, J L, Kircher, T, Kirov, G, Kittel-Schneider, S, Klöhn-Saghatolislam, F, Knowles, J A, Kranz, T M, Lagerberg, T V, Landen, M, Lawson, W B, Leboyer, M, Li, Q S, Maj, M, Malaspina, D, Manchia, M, Mayoral, F, McElroy, S L, McInnis, M G, McIntosh, A M, Medeiros, H, Melle, I, Milanova, V, Mitchell, P B, Monteleone, P, Monteleone, A M, Nöthen, M M, Novak, T, Nurnberger, J I, O'Brien, N, O'Connell, K S, O'Donovan, C, O'Donovan, M C, Opel, N, Ortiz, A, Owen, M J, Pålsson, E, Pato, C, Pato, M T, Pawlak, J, Pfarr, J K, Pisanu, C, Potash, J B, Rapaport, M H, Reich-Erkelenz, D, Reif, A, Reininghaus, E, Repple, J, Richard-Lepouriel, H, Rietschel, M, Ringwald, K, Roberts, G, Rouleau, G, Schaupp, S, Scheftner, W A, Schmitt, S, Schofield, P R, Schubert, K O, Schulte, E C, Schweizer, B, Senner, F, Severino, G, Sharp, S, Slaney, C, Smeland, O B, Sobell, J L, Squassina, A, Stopkova, P, Strauss, J, Tortorella, A, Turecki, G, Twarowska-Hauser, J, Veldic, M, Vieta, E, Vincent, J B, Xu, W, Zai, C C, Zandi, P P, Di Florio, A, Smoller, J W, Biernacka, J M, McMahon, F J, Alda, M, Müller-Myhsok, B, Koutsouleris, N, Falkai, P, Freimer, N B, Andlauer, T F M & Schulze, T G & Ophoff, R A 2021, ' Characterisation of age and polarity at onset in bipolar disorder ', British Journal of Psychiatry . https://doi.org/10.1192/bjp.2021.102, Print: 0007-1250 Online:1472-1465, The British Journal of Psychiatry, Vol. 219, No. 6
- Accession number :
- edsair.doi.dedup.....5a6fb87807cce211fe3634d1b9a66092