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Association between IL1B gene and cervical cancer susceptibility in Chinese Uygur Population: A Case–Control study
- Source :
- Molecular Genetics & Genomic Medicine, Molecular Genetics & Genomic Medicine, Vol 7, Iss 8, Pp n/a-n/a (2019)
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Background Interleukin‐1β (IL‐1B) has been recognized as a pro‐inflammatory cytokine and associated with tumorigenesis. We aimed to evaluate the contribution of IL‐1B polymorphisms to the susceptibility of cervical cancer in Chinese Uygur population. Methods Seven variants were genotyped by Agena MassARRAY platform in 267 cervical cancer patients and 302 healthy controls. Allelic, genotypic, and haplotypic association analyses adjusted for age were investigated using odds ratios (OR) and 95% confidence intervals (CI). GEPIA and UALCAN databases were used to evaluate expression and prognostic of IL‐1B gene in cervical cancer. Results Our result revealed IL‐1B rs1143627‐AA (OR = 1.98, p = 0.029) and rs16944‐GG (OR = 2.01, p = 0.025) was associated with an increased risk of cervical cancer. Besides, we also found two protective single nucleotide polymorphisms (SNPs) rs3136558 (OR = 0.63, p = 0.011) and rs1143630 (OR = 0.63, p = 0.019). Haplotype ″TGA″ in the block (rs1143630, rs1143627, and rs16944) significantly decreased the susceptibility of cervical cancer (OR = 0.53, p = 0.0007). IL‐1B mRNA level was up‐regulated in the cervical cancer patients, which was related with poor prognosis in silico. Conclusions For the first time, our results provide evidence on polymorphism of IL‐1B gene associated with cervical cancer risk in Chinese Uygur population.
- Subjects :
- 0301 basic medicine
Oncology
Case–Control study
cervical cancer
Interleukin-1beta
Uterine Cervical Neoplasms
030105 genetics & heredity
medicine.disease_cause
susceptibility
single nucleotide polymorphism
Genotype
Ethnicity
Odds Ratio
Genetics (clinical)
Cervical cancer
education.field_of_study
Middle Aged
Prognosis
Gene Expression Regulation, Neoplastic
Original Article
Female
Adult
medicine.medical_specialty
lcsh:QH426-470
Population
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
IL‐1B gene
03 medical and health sciences
Asian People
Internal medicine
Genetics
medicine
Humans
Genetic Predisposition to Disease
education
Molecular Biology
Alleles
Genetic Association Studies
Aged
business.industry
Haplotype
Case-control study
Original Articles
Odds ratio
medicine.disease
lcsh:Genetics
030104 developmental biology
Haplotypes
Case-Control Studies
Carcinogenesis
business
Subjects
Details
- ISSN :
- 23249269
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Molecular Genetics & Genomic Medicine
- Accession number :
- edsair.doi.dedup.....5a81172ff88362e1fdfbba89b9ccdfba